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Initial sequencing and comparative analysis of the mouse genome

CollaborationWith : Antonarakis, Stylianos / Couronne, Olivier / Dermitzakis, Emmanouil / Zdobnov, Evgeny
Published in Nature. 2002, vol. 420, no. 6915, p. 520-562
Abstract The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
Keywords AnimalsBase CompositionChromosomesMammalian/ geneticsConserved Sequence/geneticsCpG Islands/geneticsEvolutionMolecularGene Expression RegulationGenes/geneticsGenetic Variation/geneticsGenomeHumanGenomicsHumansMice/classification/ geneticsMiceKnockoutTransgenicModelsAnimalMultigene Family/geneticsMutagenesisNeoplasms/geneticsPhysical Chromosome MappingProteome/geneticsPseudogenes/geneticsQuantitative Trait Loci/geneticsRNAUntranslated/geneticsRepetitive SequencesNucleic Acid/geneticsSelectionGeneticSequence AnalysisDNASex Chromosomes/geneticsSpecies SpecificitySynteny
PMID: 12466850
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Research groups Epilepsie et Chirurgie (149)
Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
Population Genomics and Genetics of Complex Traits (892)
(ISO format)
MOUSE GENOME ANALYSIS GROUP. Initial sequencing and comparative analysis of the mouse genome. In: Nature, 2002, vol. 420, n° 6915, p. 520-562. https://archive-ouverte.unige.ch/unige:9091

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Deposited on : 2010-07-12

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