Initial sequencing and comparative analysis of the mouse genome

Article Article scientifique Article Initial sequencing and comparative analysis of the mouse genome eng 2002 collaborator Antonarakis Stylianos 22813 collaborator Couronne Olivier 511062 collaborator Dermitzakis Emmanouil 542683 collaborator Zdobnov Evgeny 636914 Mouse Genome Analysis Group 520-562 10.1038/nature01262 12466850 0028-0836 http://www.nature.com/nature/journal/v420/n6915/full/nature01262.html The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism. Animals Base Composition Chromosomes Mammalian/ genetics Conserved Sequence/genetics CpG Islands/genetics Evolution Molecular Gene Expression Regulation Genes/genetics Genetic Variation/genetics Genome Human Genomics Humans Mice/classification/ genetics Mice Knockout Transgenic Models Animal Multigene Family/genetics Mutagenesis Neoplasms/genetics Physical Chromosome Mapping Proteome/genetics Pseudogenes/genetics Quantitative Trait Loci/genetics RNA Untranslated/genetics Repetitive Sequences Nucleic Acid/genetics Selection Genetic Sequence Analysis DNA Sex Chromosomes/genetics Species Specificity Synteny Dewey 616 56 Département de médecine 221 false 119 Epilepsie et Chirurgie 149 196 Pathologie Moléculaire de la Trisomie 21 et le Génome Humain 248 551 Population Genomics and Genetics of Complex Traits 892 Nature 420 6915 37281c4d-1019-47ad-930e-b763c8f900ed Article Restricted file1.pdf 4340973 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Year	Views	Downloads

Initial sequencing and comparative analysis of the mouse genome	Nature	2002	803	6
An ab initio and DFT study of (N2)2 dimers	Chemical physics letters	1999	773	443

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Couronne, Olivier