IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death

Rutti Roch, Sabine; Howald, Cédric; Arous, Caroline; Dermitzakis, Emmanouil; Halban, Philippe A.; Bouzakri, Karim

doi:10.1016/j.molmet.2015.11.003

Scientific article

English

IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death

ContributorsRutti Roch, Sabine; Howald, Cédric; Arous, Caroline; Dermitzakis, Emmanouil; Halban, Philippe A.; Bouzakri, Karim

Published inMolecular metabolism, vol. 5, no. 2, p. 122-131

Publication date2016

Abstract

IL-13 is a cytokine classically produced by anti-inflammatory T-helper-2 lymphocytes; it is decreased in the circulation of type 2 diabetic patients and impacts positively on liver and skeletal muscle. Although IL-13 can exert positive effects on beta-cell lines, its impact and mode of action on primary beta-cell function and survival remain largely unexplored.

Affiliation entities

Research groups

Population Genomics and Genetics of Complex Traits (892)

Citation (ISO format)

RUTTI ROCH, Sabine et al. IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death. In: Molecular metabolism, 2016, vol. 5, n° 2, p. 122–131. doi: 10.1016/j.molmet.2015.11.003

Article (Published version)

CC BY-NC-ND

Identifiers

PID : unige:89645
DOI : 10.1016/j.molmet.2015.11.003
PMID : 26909320

Journal ISSN2212-8778

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Creation23/11/2016 15:45:00

First validation23/11/2016 15:45:00

Update15/03/2023 01:02:23

Status update15/03/2023 01:02:23

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IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death

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