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Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
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IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death | Molecular metabolism | 2016 | 493 | 136 | |||
Short Term Exposure of Beta Cells to Low Concentrations of Interleukin-1β Improves Insulin Secretion through Focal Adhesion and Actin Remodeling and Regulation of Gene Expression | The Journal of biological chemistry | 2015 | 536 | 2 | |||
Fractalkine (CX3CL1), a new factor protecting β-cells against TNFα | Molecular metabolism | 2014 | 606 | 359 | |||
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment | Diabetes care | 2014 | 790 | 655 | |||
Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells | FEBS letters | 2014 | 724 | 365 | |||
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment | The Journal of clinical endocrinology and metabolism | 2014 | 634 | 850 | |||
Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats | PloS one | 2014 | 631 | 231 | |||
Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model | Diabetologia | 2013 | 557 | 355 | |||
Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion | Diabetologia | 2013 | 552 | 1,393 | |||
Cell-type, allelic and genetic signatures in the human pancreatic beta cell transcriptome | Genome research | 2013 | 662 | 454 | |||
Autonomous and self-sustained circadian oscillators displayed in human islet cells | Diabetologia | 2013 | 663 | 153 | |||
A new paradigm for improved co-ordination and efficacy of European biomedical research: taking diabetes as a model | Diabetologia | 2013 | 584 | 361 | |||
In vitro proliferation of adult human beta-cells | PloS one | 2012 | 682 | 410 | |||
Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease | Diabetes, obesity & metabolism | 2012 | 641 | 704 | |||
Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion | The Journal of biological chemistry | 2012 | 648 | 418 | |||
Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin | Diabetes | 2011 | 579 | 299 | |||
Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat | Diabetologia | 2011 | 639 | 380 | |||
Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle | Diabetes | 2011 | 590 | 2 | |||
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells | Nature medicine | 2011 | 788 | 749 | |||
Prime time for DIAMAP: a road map for diabetes research in Europe | Diabetologia | 2010 | 489 | 159 | |||
Cytokine production by islets in health and diabetes: cellular origin, regulation and function | Trends in endocrinology and metabolism | 2010 | 490 | 1 | |||
Current status of islet cell replacement and regeneration therapy | The Journal of clinical endocrinology and metabolism | 2010 | 570 | 0 | |||
Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate | Traffic | 2010 | 529 | 0 | |||
Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion | The Journal of biological chemistry | 2009 | 592 | 0 | |||
Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix | Molecular endocrinology | 2009 | 538 | 0 | |||
Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function | Endocrinology | 2009 | 635 | 0 | |||
Order! Order! Order in the House! DIAMAP: a road map for European diabetes research | Diabetologia | 2008 | 501 | 111 | |||
Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture | Diabetes | 2008 | 583 | 0 | |||
Interleukin-6 regulates pancreatic alpha-cell mass expansion | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 547 | 0 | |||
Proliferation of sorted human and rat beta cells | Diabetologia | 2008 | 817 | 190 | |||
The right stuff: beta-cell channels, cycles, and sensors | American journal of physiology: endocrinology and metabolism | 2008 | 514 | 0 | |||
Munc 18-1 and granuphilin collaborate during insulin granule exocytosis | Traffic | 2008 | 650 | 0 | |||
Cell therapy for type 2 diabetes: is it desirable and can we get it? | Diabetes, obesity & metabolism | 2008 | 581 | 0 | |||
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells | Diabetes | 2008 | 576 | 0 | |||
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation | The Journal of clinical endocrinology and metabolism | 2008 | 603 | 252 | |||
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14 | Diabetes | 2008 | 528 | 1,403 | |||
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion | Endocrinology | 2008 | 605 | 0 | |||
Dynamin is functionally coupled to insulin granule exocytosis | The Journal of biological chemistry | 2007 | 605 | 0 | |||
Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells | Endocrinology | 2007 | 534 | 0 | |||
The innovative medicines initiative (IMI): a shot in the arm for European diabetes research? | Diabetologia | 2007 | 559 | 152 | |||
The Fas pathway is involved in pancreatic beta cell secretory function | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 635 | 0 | |||
Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity | Journal of Endocrinology | 2007 | 546 | 0 | |||
Comment faire renaître la cellule beta du sacrifice en sauveur | Journées annuelles de diabétologie de l'Hôtel-Dieu | 2007 | 456 | 0 | |||
Pro-survival role of gelsolin in mouse beta-cells | Diabetes | 2007 | 486 | 0 | |||
Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice | Diabetes | 2007 | 571 | 0 | |||
Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix | Diabetes | 2006 | 583 | 0 | |||
Diabetes research investment in the European Union | Nature medicine | 2006 | 541 | 0 | |||
Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat | Diabetes | 2006 | 984 | 0 | |||
Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway | Journal of cell science | 2006 | 539 | 205 | |||
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death | Diabetes | 2006 | 603 | 0 | |||
10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it? | Diabetologia | 2005 | 459 | 0 | |||
Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells | The Journal of biological chemistry | 2005 | 482 | 172 | |||
Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells | Diabetologia | 2005 | 610 | 156 | |||
Sorting ourselves out: seeking consensus on trafficking in the beta-cell | Traffic | 2004 | 460 | 0 | |||
Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways | Diabetes | 2004 | 595 | 615 | |||
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide | Diabetes | 2004 | 500 | 0 | |||
Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications | Diabetologia | 2004 | 532 | 0 | |||
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 554 | 0 | |||
Towards a perfect beta cell replacement | Seminars in cell & developmental biology | 2004 | 515 | 0 | |||
Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta | The Journal of clinical endocrinology and metabolism | 2004 | 575 | 0 | |||
Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine | Nature cell biology | 2004 | 449 | 0 | |||
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis | The Journal of biological chemistry | 2003 | 525 | 0 | |||
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse | Diabetes | 2003 | 513 | 0 | |||
Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway | Molecular biology of the cell | 2003 | 524 | 0 | |||
Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines | Endocrinology | 2003 | 488 | 1 | |||
Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex | Molecular endocrinology | 2003 | 576 | 0 | |||
Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription | Diabetologia | 2003 | 652 | 149 | |||
Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion | Biochemical journal | 2002 | 577 | 0 | |||
FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 742 | 219 | |||
Truncated (des-[27-31]) C-peptide is not a major secretory product of human islets | Diabetologia | 2002 | 556 | 0 | |||
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets | The Journal of clinical investigation | 2002 | 771 | 208 | |||
Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor | Journal of neurochemistry | 2002 | 539 | 0 | |||
Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro | Diabetologia | 2002 | 793 | 0 | |||
Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? | Diabetes | 2001 | 569 | 0 | |||
Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix | Diabetes | 2001 | 570 | 0 | |||
NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro | Diabetologia | 2001 | 591 | 0 | |||
Role of clathrin in the regulated secretory pathway of pancreatic beta-cells | Journal of cell science | 2001 | 427 | 73 | |||
Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells | Biochemical journal | 2001 | 533 | 0 | |||
Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin | Diabetes | 2000 | 524 | 0 | |||
Sponsor, leader and lobbyist: the European Foundation for the Study of Diabetes (EFSD) and the future of diabetes research in Europe | Diabetologia | 2000 | 584 | 0 | |||
Trafficking of non-regulated secretory proteins in insulin secreting (INS-1) cells | Diabetologia | 2000 | 589 | 0 | |||
Trafficking/sorting and granule biogenesis in the beta-cell | Seminars in cell & developmental biology | 2000 | 558 | 0 | |||
Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells | Journal of cell science | 2000 | 1,155 | 314 | |||
SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion | Biochemical journal | 1999 | 506 | 0 | |||
Storage of tissue-type plasminogen activator in Weibel-Palade bodies of human endothelial cells | Arteriosclerosis, thrombosis, and vascular biology | 1999 | 571 | 0 | |||
Blockade of membrane transport and disassembly of the Golgi complex by expression of syntaxin 1A in neurosecretion-incompetent cells: prevention by rbSEC1 | Journal of cell science | 1999 | 467 | 202 | |||
Insulin resistance in HIV protease inhibitor-associated diabetes | Journal of acquired immune deficiency syndromes | 1999 | 641 | 0 | |||
The GM2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is not beta-cell specific | Endocrinology | 1998 | 514 | 0 | |||
Vascularization of purified pancreatic islet-like cell aggregates (pseudoislets) after syngeneic transplantation | Diabetes | 1998 | 528 | 0 | |||
Sorting human beta-cells consequent to targeted expression of green fluorescent protein | Diabetes | 1998 | 734 | 0 | |||
Identification and characterization of alpha 3 beta 1 integrin on primary and transformed rat islet cells | Experimental cell research | 1997 | 539 | 0 | |||
Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia | Diabetologia | 1997 | 682 | 182 | |||
Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E-deficient Cpefat/Cpefat mice | The Journal of biological chemistry | 1997 | 530 | 0 | |||
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression | Diabetes | 1997 | 593 | 0 | |||
Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1 | The Journal of biological chemistry | 1997 | 597 | 0 | |||
SNAP-25 can self-associate to form a disulfide-linked complex | Biological chemistry | 1997 | 523 | 0 | |||
Insulin production: from gene to granule | Diabetologia | 1997 | 507 | 0 | |||
Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon | FEBS letters | 1997 | 562 | 0 | |||
Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM | Diabetes | 1997 | 584 | 0 | |||
Proinsulin conversion in GH3 cells after coexpression of human proinsulin with the endoproteases PC2 and/or PC3 | Diabetes | 1997 | 525 | 0 | |||
SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion | The Journal of biological chemistry | 1997 | 585 | 0 | |||
Inositol 1,4,5-trisphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 575 | 0 | |||
Des-(27-31)C-peptide. A novel secretory product of the rat pancreatic beta cell produced by truncation of proinsulin connecting peptide in secretory granules | The Journal of biological chemistry | 1996 | 575 | 0 | |||
Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis | EMBO journal | 1996 | 512 | 0 | |||
Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus | Biochemical journal | 1996 | 502 | 0 | |||
Sequence requirements for proinsulin processing at the B-chain/C-peptide junction | Biochemical journal | 1995 | 572 | 0 | |||
SNAP-25 is expressed in islets of Langerhans and is involved in insulin release | The Journal of cell biology | 1995 | 537 | 0 | |||
Processing of proinsulin by furin, PC2, and PC3 in (co) transfected COS (monkey kidney) cells | Diabetes | 1995 | 597 | 0 | |||
Publish and flourish: seasonal advice to our readers | Diabetologia | 1995 | 546 | 0 | |||
Molecular strategies for the treatment of diabetes | Transplantation proceedings | 1994 | 499 | 0 | |||
Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells | The Journal of biological chemistry | 1994 | 529 | 0 | |||
Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells | Biochemical journal | 1994 | 530 | 0 | |||
Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation | Journal of cell science | 1994 | 530 | 168 | |||
Proinsulin processing in the regulated and the constitutive secretory pathway | Diabetologia | 1994 | 570 | 0 | |||
Sorting and processing of secretory proteins | Biochemical journal | 1994 | 563 | 0 | |||
pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle | The Journal of cell biology | 1994 | 607 | 0 | |||
Hypoglycaemia caused by atypical insulin antibodies in a patient with benign monoclonal gammopathy | Journal of internal medicine | 1993 | 469 | 0 | |||
Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells | The Journal of biological chemistry | 1993 | 526 | 0 | |||
Kinetics of proinsulin conversion in human islets | Diabetes | 1993 | 516 | 0 | |||
Novel, non-crinophagic, degradation of connecting peptide in transformed pancreatic beta cells | The Journal of biological chemistry | 1993 | 464 | 0 | |||
Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells | Diabetologia | 1993 | 539 | 0 | |||
B-cell size influences glucose-stimulated insulin secretion | The American journal of physiology | 1993 | 561 | 0 | |||
Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells | The Journal of clinical investigation | 1993 | 577 | 0 | |||
Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of posttranscriptional regulation | The Journal of clinical investigation | 1993 | 604 | 0 | |||
Processing of proinsulin by transfected hepatoma (FAO) cells | The Journal of biological chemistry | 1992 | 529 | 0 | |||
The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs | Molecular and cellular endocrinology | 1992 | 596 | 0 | |||
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines | Endocrinology | 1992 | 790 | 0 | |||
Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II | Biochemical journal | 1991 | 555 | 0 | |||
Biosynthèse de l'insuline: trafic intracellulaire et transformations enzymatiques | Journées annuelles de diabétologie de l'Hôtel-Dieu | 1991 | 531 | 0 | |||
Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell | Diabetologia | 1991 | 564 | 0 | |||
Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cell types | Developmental biology | 1991 | 532 | 0 | |||
Proinsulin conversion intermediates: a possible source of confusion | Diabetologia | 1991 | 531 | 0 | |||
Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells | Molecular endocrinology | 1991 | 466 | 0 | |||
Proinsulin trafckin and processing in the pancreatic B cell | Trends in endocrinology and metabolism | 1990 | 561 | 0 | |||
Establishment and culture of insulin-secreting beta cell lines | Methods in enzymology | 1990 | 411 | 0 | |||
High-performance liquid chromatography analysis of circulating insulins distinguishes between endogenous insulin production (a potential pitfall with streptozotocin diabetic rats) and islet xenograft function | Diabetologia | 1990 | 544 | 0 | |||
Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types | Experimental cell research | 1990 | 575 | 0 | |||
Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells | Methods in enzymology | 1990 | 535 | 0 | |||
Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 552 | 0 | |||
Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells | The Journal of biological chemistry | 1989 | 561 | 0 | |||
Oxidation of rat insulin II, but not I, leads to anomalous elution profiles upon HPLC analysis of insulin-related peptides | FEBS letters | 1988 | 557 | 0 | |||
Effects of aging on insulin synthesis and secretion. Differential effects on preproinsulin messenger RNA levels, proinsulin biosynthesis, and secretion of newly made and preformed insulin in the rat | The Journal of clinical investigation | 1988 | 605 | 0 | |||
Altered differentiated cell surface properties of transformed (RINm5F) compared with native adult rat pancreatic B cells | Endocrinology | 1988 | 591 | 0 | |||
Islet B-cell dysfunction and the time course of recovery following chronic overinsulinisation of normal rats | Diabetologia | 1988 | 565 | 0 | |||
The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide | Biochemical journal | 1988 | 535 | 0 | |||
Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway | The Journal of cell biology | 1987 | 550 | 0 | |||
Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump | The Journal of biological chemistry | 1987 | 564 | 0 | |||
Resistance of the insulin crystal to lysosomal proteases: implications for pancreatic B-cell crinophagy | Diabetologia | 1987 | 615 | 0 | |||
Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets | Diabetes | 1987 | 680 | 0 | |||
Tris(hydroxymethyl)aminomethane inhibits the synthesis and processing of proinsulin in isolated rat pancreatic islets without affecting release of insulin stores | Diabetes | 1986 | 596 | 0 | |||
Identification of functional insulin receptors on membranes from an insulin-producing cell line (RINm5F) | Biochemical journal | 1985 | 501 | 0 | |||
A new, rapid, method for preparation of dispersed pancreatic acini | Biochemical journal | 1985 | 489 | 0 | |||
Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment | The Journal of cell biology | 1984 | 554 | 0 | |||
Dispersed adult rat pancreatic islet cells in culture: A, B, and D cell function | Metabolism, clinical and experimental | 1984 | 655 | 0 | |||
Proinsulin modified by analogues of arginine and lysine is degraded rapidly in pancreatic B-cells | Biochemical journal | 1984 | 566 | 0 | |||
A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin | Cell | 1984 | 605 | 0 | |||
Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell | The Journal of cell biology | 1984 | 617 | 0 | |||
Elevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus | Diabetes | 1983 | 553 | 0 | |||
In vivo modulation of gap junctions and dye coupling between B-cells of the intact pancreatic islet | Diabetes | 1983 | 515 | 0 | |||
Regulation of immunoreactive-insulin release from a rat cell line (RINm5F) | Biochemical journal | 1983 | 601 | 0 | |||
Influence of glucose on insulin handling by rat islets in culture. A reflection of integrated changes in insulin biosynthesis, release, and intracellular degradation | Diabetes | 1983 | 570 | 0 | |||
Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F) | Biochemical journal | 1983 | 542 | 0 | |||
Differential rates of release of newly synthesized and of stored insulin from pancreatic islets | Endocrinology | 1982 | 590 | 0 | |||
The possible importance of contact between pancreatic islet cells for the control of insulin release | Endocrinology | 1982 | 604 | 0 | |||
Inhibition of proinsulin to insulin conversion in rat islets using arginine and lysine analogs. Lack of effect on rate of release of modified products | The Journal of biological chemistry | 1982 | 515 | 0 | |||
Functional differences between rat islets of ventral and dorsal pancreatic origin | The Journal of clinical investigation | 1982 | 587 | 0 | |||
Biologic activity and pharmacokinetics of biosynthetic human insulin in the rat | Diabetes care | 1981 | 573 | 0 | |||
Degradation of pork insulin and biosynthetic human insulin in vitro and in vivo: a comparative study | Endocrine research communications | 1981 | 549 | 0 | |||
Insulin degradation by hepatocytes in primary culture | Endocrinology | 1981 | 594 | 0 | |||
Increased clearance and degradation of [3H]insulin in streptozotocin diabetic rats | The Journal of clinical investigation | 1981 | 558 | 0 | |||
In vitro studies on biosynthetic human insulin: an overview | Diabetes care | 1981 | 584 | 0 | |||
Internalization of 125I-insulin by IM-9 cultured human lymphocytes: a comparison between A14-monoiodo-pork and biosynthetic human insulin | Diabetes care | 1981 | 587 | 0 | |||
The effect of aprotinin on the absorption of subcutaneously injected regular insulin in normal subjects | Diabetes | 1980 | 639 | 0 | |||
Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the beta cell | Biochemical pharmacology | 1980 | 534 | 0 | |||
Gap junction development is correlated with insulin content in the pancreatic B cell | Science | 1980 | 490 | 0 | |||
In vitro and in vivo studies on glucagonoma tissue | Hormone and metabolic research | 1980 | 611 | 0 | |||
Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content | The Journal of biological chemistry | 1980 | 529 | 0 | |||
Binding and degradation of semisynthetic tritiated insulin by IM-9 cultured human lymphocytes | Diabetes | 1980 | 604 | 0 | |||
Resistance against subcutaneous insulin successfully managed with aprotinin | Lancet | 1980 | 629 | 0 | |||
Pharmacokinetics of subcutaneously injected tritiated insulin: effects of exercise | Diabetes | 1979 | 569 | 0 | |||
Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site | Diabetologia | 1979 | 551 | 0 | |||
Perturbation of hormone storage and release induced by cyproheptadine in rat pancreatic islets in vitro | Endocrinology | 1979 | 568 | 0 | |||
Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor | Biochemical journal | 1979 | 601 | 0 | |||
Distribution and metabolism of intravenously injected tritiated insulin in rats | Metabolism, clinical and experimental | 1979 | 571 | 0 | |||
Isolation of pancreatic islets of Langerhans by filtration on nylon mesh | Biochemical and biophysical research communications | 1978 | 584 | 0 | |||
Mobilization of subcutaneously injected tritiated insulin in rats: effects of muscular exercise | Diabetologia | 1978 | 599 | 0 | |||
The degradation of semisynthetic tritiated insulin by perfused mouse livers | Biochemical journal | 1976 | 556 | 0 |