UNIGE document Scientific Article
previous document  unige:88595  next document
add to browser collection
Title

IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity

Authors
Duraes, Fernanda V
Irla, Magali
show hidden authors show all authors [1 - 10]
Published in Journal of Autoimmunity. 2016
Abstract Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent on MHCII-mediated, antigen-dependent, interactions with Treg. We further established that IDO production by pDCs was necessary to confer suppressive function to Tregs. During EAE development, IDO expression by pDCs was required for the generation of Tregs capable of dampening the priming of encephalitogenic T cell and disease severity. Thus, we describe a novel crosstalk between pDCs and Tregs: Tregs shape tolerogenic functions of pDCs prior to inflammation, such that pDCs in turn, promote Treg suppressive functions during autoimmunity.
Identifiers
PMID: 27470005
Full text
Article (Published version) (1.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pathologie et immunologie (906)
Citation
(ISO format)
LIPPENS, Carla et al. IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity. In: Journal of Autoimmunity, 2016. https://archive-ouverte.unige.ch/unige:88595

97 hits

4 downloads

Update

Deposited on : 2016-11-02

Export document
Format :
Citation style :