IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity

Lippens, Carla; Duraes, Fernanda V; Dubrot Armendariz, Juan; Brighouse, Dale; Lacroix, Mathilde; Irla, Magali; Aubry-Lachainaye, Jean-Pierre; Reith, Walter; Mandl, Judith N; Hugues, Stéphanie

doi:10.1016/j.jaut.2016.07.004

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Title		IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
Authors		Lippens, Carla Duraes, Fernanda V Dubrot Armendariz, Juan Brighouse, Dale Lacroix, Mathilde Irla, Magali Aubry-Lachainaye, Jean-Pierre Reith, Walter Mandl, Judith N Hugues, Stéphanie show all authors [1 - 10]
Published in		Journal of Autoimmunity. 2016, vol. 75, p. 39-49
Abstract		Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent on MHCII-mediated, antigen-dependent, interactions with Treg. We further established that IDO production by pDCs was necessary to confer suppressive function to Tregs. During EAE development, IDO expression by pDCs was required for the generation of Tregs capable of dampening the priming of encephalitogenic T cell and disease severity. Thus, we describe a novel crosstalk between pDCs and Tregs: Tregs shape tolerogenic functions of pDCs prior to inflammation, such that pDCs in turn, promote Treg suppressive functions during autoimmunity.
Identifiers		DOI: 10.1016/j.jaut.2016.07.004 PMID: 27470005
Full text		Article (Published version) (1.6 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Pathologie et immunologie (906)
Citation (ISO format)		LIPPENS, Carla et al. IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity. In: Journal of Autoimmunity, 2016, vol. 75, p. 39-49. https://archive-ouverte.unige.ch/unige:88595