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IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity

Duraes, Fernanda V
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Published in Journal of autoimmunity. 2016, vol. 75, p. 39-49
Abstract Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent on MHCII-mediated, antigen-dependent, interactions with Treg. We further established that IDO production by pDCs was necessary to confer suppressive function to Tregs. During EAE development, IDO expression by pDCs was required for the generation of Tregs capable of dampening the priming of encephalitogenic T cell and disease severity. Thus, we describe a novel crosstalk between pDCs and Tregs: Tregs shape tolerogenic functions of pDCs prior to inflammation, such that pDCs in turn, promote Treg suppressive functions during autoimmunity.
PMID: 27470005
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Research groups Groupe Reith Walter (pathologie et immunologie) (282)
Pathologie et immunologie (906)
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LIPPENS, Carla et al. IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity. In: Journal of autoimmunity, 2016, vol. 75, p. 39-49. doi: 10.1016/j.jaut.2016.07.004 https://archive-ouverte.unige.ch/unige:88595

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Deposited on : 2016-11-02

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