IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity

Article Article scientifique Article IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity eng 2016 author Lippens Carla 765790 author Duraes Fernanda V author Dubrot Armendariz Juan 744966 author Brighouse Dale 134767 author Lacroix Mathilde 848976 author Irla Magali 638461 author Aubry-Lachainaye Jean-Pierre 772875 author Reith Walter 25482 author Mandl Judith N author Hugues Stéphanie 663452 39-49 10.1016/j.jaut.2016.07.004 27470005 0896-8411 Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent on MHCII-mediated, antigen-dependent, interactions with Treg. We further established that IDO production by pDCs was necessary to confer suppressive function to Tregs. During EAE development, IDO expression by pDCs was required for the generation of Tregs capable of dampening the priming of encephalitogenic T cell and disease severity. Thus, we describe a novel crosstalk between pDCs and Tregs: Tregs shape tolerogenic functions of pDCs prior to inflammation, such that pDCs in turn, promote Treg suppressive functions during autoimmunity. Dewey 616.07 137 Département de pathologie et immunologie 21F false 221 Groupe Reith Walter (pathologie et immunologie) 282 563 Pathologie et immunologie 906 Journal of autoimmunity 75 8917ec10-ee5c-45d5-8753-f311aa152728 Article (Published version) Public Lippens.pdf 1655484 application/pdf CC BY-NC-ND openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity	Journal of autoimmunity			2016	665	793

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Lacroix, Mathilde