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Title

Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F)

Authors
Praz, G. A.
Published in Biochemical Journal. 1983, vol. 212, no. 2, p. 439-443
Abstract Glucose metabolism and insulin release were studied in isolated rat islets and in an insulin-producing rat cell-line (RINm5F). Intact islets displayed two components of glucose utilization, with glucose stimulation of insulin release being associated with the high-Km component (reflecting glucokinase-like activity). Glucose failed to stimulate insulin release from RINm5F cells, which only displayed a single low-Km component of glucose utilization. Only low-Km (hexokinase-like) glucose-phosphorylating activity was found for disrupted RINm5F cells. These changes in glucose metabolism may contribute towards the failure of glucose to stimulate insulin release from RINm5F cells.
Keywords AnimalsCell LineGlucose/ metabolism/pharmacologyInsulin/immunology/ metabolismIslets of Langerhans/drug effects/metabolismMalePancreas/drug effects/ metabolismRatsRats, Inbred StrainsSonicationStimulation, Chemical
Identifiers
PMID: 6349618
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HALBAN, Philippe A., PRAZ, G. A., WOLLHEIM, Claes. Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F). In: Biochemical Journal, 1983, vol. 212, n° 2, p. 439-443. https://archive-ouverte.unige.ch/unige:8790

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Deposited on : 2010-07-12

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