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Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex

Published in Science. 2016, vol. 351, no. 6280, p. 1443-1446
Abstract During corticogenesis, excitatory neurons are born from progenitors located in the ventricular zone (VZ), from where they migrate to assemble into circuits. How neuronal identity is dynamically specified upon progenitor division is unknown. Here, we study this process using a high-temporal-resolution technology allowing fluorescent tagging of isochronic cohorts of newborn VZ cells. By combining this in vivo approach with single-cell transcriptomics in mice, we identify and functionally characterize neuron-specific primordial transcriptional programs as they dynamically unfold. Our results reveal early transcriptional waves that instruct the sequence and pace of neuronal differentiation events, guiding newborn neurons toward their final fate, and contribute to a road map for the reverse engineering of specific classes of cortical neurons from undifferentiated cells.
Keywords AnimalsBasic Helix-Loop-Helix Transcription Factors/geneticsCerebral Ventricles/cytology/embryologyDNA-Binding Proteins/geneticsFemaleGPI-Linked Proteins/geneticsGreen Fluorescent Proteins/geneticsMaleMiceNeocortex/cytology/embryologyNerve Tissue Proteins/geneticsNeural Stem Cells/cytologyNeurogenesis/geneticsNeurons/cytologyNeuropeptides/geneticsSOXB1 Transcription Factors/geneticsTranscription, GeneticTranscriptome
PMID: 26940868
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Research groups Groupe Dayer Alexandre (Formation du circuit cortical) (875)
Mécanismes moléculaires et génétiques du développement sexuel (778)
Neurobiologie développementale et plasticité (880)
Population Genomics and Genetics of Complex Traits (892)
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TELLEY, Ludovic et al. Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. In: Science, 2016, vol. 351, n° 6280, p. 1443-1446. doi: 10.1126/science.aad8361 https://archive-ouverte.unige.ch/unige:86827

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Deposited on : 2016-09-06

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