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Doctoral thesis
Open access
English

In silico-driven strategies for the identification of novel sirtuin modulators

ContributorsSacconnay, Lionel
Defense date2016-02-26
Abstract

Sirtuin proteins (SIRTs) are histone deacetylases (HDACs) involved in cellular processes such as gene transcription and cell cycle regulation. Recently, their chemical modulation was found to be beneficial against aging-related and neglected tropical diseases. In this manuscript, computational tools coupled with enzymatic and cellular assays provided (i) new insight on SIRT structures, describing for the first time the structural features of the SIRT2-c-Src complex; (ii) novel compounds with therapeutic potential able to inhibit SIRT activities.

eng
Keywords
  • Sirtuin
  • HDAC
  • In silico
  • Virtual Screening
  • Molecular Dynamic
  • Modulators
  • PPI
Research group
Citation (ISO format)
SACCONNAY, Lionel. In silico-driven strategies for the identification of novel sirtuin modulators. 2016. doi: 10.13097/archive-ouverte/unige:83714
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Creation05/13/2016 10:54:00 AM
First validation05/13/2016 10:54:00 AM
Update time03/15/2023 12:20:41 AM
Status update03/15/2023 12:20:41 AM
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