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In silico-driven strategies for the identification of novel sirtuin modulators

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Defense Thèse de doctorat : Univ. Genève, 2016 - Sc. 4904 - 2016/02/26
Abstract Sirtuin proteins (SIRTs) are histone deacetylases (HDACs) involved in cellular processes such as gene transcription and cell cycle regulation. Recently, their chemical modulation was found to be beneficial against aging-related and neglected tropical diseases. In this manuscript, computational tools coupled with enzymatic and cellular assays provided (i) new insight on SIRT structures, describing for the first time the structural features of the SIRT2-c-Src complex; (ii) novel compounds with therapeutic potential able to inhibit SIRT activities.
Keywords Sirtuin - HDAC - In silico - Virtual Screening - Molecular Dynamic - Modulators - PPI
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URN: urn:nbn:ch:unige-837144
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Research group Pharmacochimie
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SACCONNAY, Lionel. In silico-driven strategies for the identification of novel sirtuin modulators. Université de Genève. Thèse, 2016. https://archive-ouverte.unige.ch/unige:83714

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Deposited on : 2016-05-18

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