Scientific article
Open access

Interdependence of filamentous actin and microtubules for asymmetric cell division

Published inBiological chemistry, vol. 381, no. 9-10, p. 815-825
Publication date2000

Asymmetric cell divisions are crucial to the generation of cell fate diversity. They contribute to unequal distribution of cellular factors to the daughter cells. Asymmetric divisions are characterized by a 90 degrees rotation of the mitotic spindle. There is increasing evidence that a tight cooperation between cortical, filamentous actin and astral microtubules is indispensable for successful spindle rotation. Over the past years, the dynactin complex has emerged as a key candidate to mediate actin/microtubule interaction at the cortex. This review discusses our current understanding of how spindle rotation is accomplished by the interplay of filamentous actin and microtubules in a variety of experimental systems.

  • Ascidian embryos
  • Asymmetric cell division
  • Dynactin
  • Pelvetia
  • Saccharomyces cerevisiae
  • Xenopus
Affiliation Not a UNIGE publication
Citation (ISO format)
SCHAER, Claudia, RIEZMAN, Howard. Interdependence of filamentous actin and microtubules for asymmetric cell division. In: Biological chemistry, 2000, vol. 381, n° 9-10, p. 815–825. doi: 10.1515/BC.2000.104
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Article (Published version)
ISSN of the journal1431-6730

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