Scientific Article
previous document  unige:82644  next document
add to browser collection

Interdependence of filamentous actin and microtubules for asymmetric cell division

Published in Biological Chemistry. 2000, vol. 381, no. 9-10, p. 815-825
Abstract Asymmetric cell divisions are crucial to the generation of cell fate diversity. They contribute to unequal distribution of cellular factors to the daughter cells. Asymmetric divisions are characterized by a 90 degrees rotation of the mitotic spindle. There is increasing evidence that a tight cooperation between cortical, filamentous actin and astral microtubules is indispensable for successful spindle rotation. Over the past years, the dynactin complex has emerged as a key candidate to mediate actin/microtubule interaction at the cortex. This review discusses our current understanding of how spindle rotation is accomplished by the interplay of filamentous actin and microtubules in a variety of experimental systems.
Keywords Ascidian embryosAsymmetric cell divisionDynactinPelvetiaSaccharomyces cerevisiaeXenopus
PMID: 11076014
Full text
Article (Published version) (273 Kb) - public document Free access
(ISO format)
SCHAER, Claudia, RIEZMAN, Howard. Interdependence of filamentous actin and microtubules for asymmetric cell division. In: Biological Chemistry, 2000, vol. 381, n° 9-10, p. 815-825.

143 hits



Deposited on : 2016-04-12

Export document
Format :
Citation style :