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Title

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains

Authors
Yang, S. J.
Xiong, Y. Q.
Dunman, Paul
Peschel, Andreas
Bayer, A. S.
Published in Antimicrobial Agents and Chemotherapy. 2009, vol. 53, no. 6, p. 2636-2637
Abstract We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.
Keywords Aminoacyltransferases/ genetics/physiologyAnti-Bacterial Agents/ pharmacologyBacterial Proteins/ genetics/physiologyDaptomycin/ pharmacologyDrug Resistance, BacterialHumansMicrobial Sensitivity TestsMutationStaphylococcus aureus/ drug effects/genetics
Identifiers
PMID: 19289517
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YANG, S. J. et al. Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains. In: Antimicrobial Agents and Chemotherapy, 2009, vol. 53, n° 6, p. 2636-2637. https://archive-ouverte.unige.ch/unige:7695

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Deposited on : 2010-06-21

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