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Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains

Yang, S. J.
Xiong, Y. Q.
Dunman, Paul
Peschel, Andreas
Bayer, A. S.
Published in Antimicrobial Agents and Chemotherapy. 2009, vol. 53, no. 6, p. 2636-2637
Abstract We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.
Keywords Aminoacyltransferases/ genetics/physiologyAnti-Bacterial Agents/ pharmacologyBacterial Proteins/ genetics/physiologyDaptomycin/ pharmacologyDrug Resistance, BacterialHumansMicrobial Sensitivity TestsMutationStaphylococcus aureus/ drug effects/genetics
PMID: 19289517
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YANG, S. J. et al. Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains. In: Antimicrobial Agents and Chemotherapy, 2009, vol. 53, n° 6, p. 2636-2637. https://archive-ouverte.unige.ch/unige:7695

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Deposited on : 2010-06-21

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