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Scientific article
English

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains

Published inAntimicrobial agents and chemotherapy, vol. 53, no. 6, p. 2636-2637
Publication date2009
Abstract

We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.

Keywords
  • Aminoacyltransferases/ genetics/physiology
  • Anti-Bacterial Agents/ pharmacology
  • Bacterial Proteins/ genetics/physiology
  • Daptomycin/ pharmacology
  • Drug Resistance, Bacterial
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Staphylococcus aureus/ drug effects/genetics
Citation (ISO format)
YANG, S. J. et al. Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains. In: Antimicrobial agents and chemotherapy, 2009, vol. 53, n° 6, p. 2636–2637. doi: 10.1128/AAC.01415-08
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ISSN of the journal0066-4804
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