The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans

van de Berg, Raymond; Guinand, Nils; Nguyen, T A Khoa; Ranieri, Maurizio; Cavuscens, Samuel; Guyot, Jean-Philippe; Stokroos, Robert; Kingma, Herman; Perez Fornos, Angelica

doi:10.3389/fnsys.2014.00255

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Title		The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans
Authors		van de Berg, Raymond Guinand, Nils Nguyen, T A Khoa Ranieri, Maurizio Cavuscens, Samuel Guyot, Jean-Philippe Stokroos, Robert Kingma, Herman Perez Fornos, Angelica show all authors [1 - 9]
Published in		Frontiers in systems neuroscience. 2014, vol. 8, no. 255
Abstract		The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the "natural" VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the "natural" VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the "normal" vestibular system.
Identifiers		DOI: 10.3389/fnsys.2014.00255 PMID: 25653601
Full text		Article (Published version) (12.3 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group		Neuroprothèses sensorielles pour la restitution de l'audition et l'équilibre (268)
Citation (ISO format)		VAN DE BERG, Raymond et al. The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans. In: Frontiers in systems neuroscience, 2014, vol. 8, n° 255. doi: 10.3389/fnsys.2014.00255 https://archive-ouverte.unige.ch/unige:75015