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Title

A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and omega-3 fatty acids in HIV-infected patients. Swiss HIV Cohort Study

Authors
Karsegard, V.
Slosman, D. O.
Published in AIDS. 1998, vol. 12, no. 1, p. 53-63
Abstract OBJECTIVE: To evaluate the effects of an oral nutritional supplement enriched with two potentially immunostimulant compounds (arginine and omega-3 fatty acids) on the changes in food intake, body composition, immune parameters and viraemia in HIV-infected outpatients. DESIGN: Six-month prospective randomized double-blind controlled study. SETTING: University hospital outpatient nutrition clinic. PATIENTS: Sixty-four HIV-infected outpatients with CD4 lymphocyte count > or = 10O x 10(6)/l. INTERVENTION: All patients received a daily oral nutritional supplement (606 kcal supplemented with vitamins, trace elements and minerals). In addition, half of the patients were randomized to receive 7.4 g arginine plus 1.7 g omega-3 fatty acids. MAIN OUTCOME MEASURES: Disease progression measured by AIDS-defining events, CD4 and CD8 lymphocyte counts, viraemia, tumour necrosis factor soluble receptors, nutritional status determined by anthropometric, bioelectrical impedance and dietetic assessment. RESULTS: Fifty-five patients completed the protocol. Compliance with and tolerance of oral nutritional supplement during the 6-month period was excellent. In both groups of patients the following were found: total energy intake was transiently increased and then returned to baseline level; nitrogen/energy intake ratio was increased throughout the study; gain of body weight and fat mass were approximately 2 and 1kg, respectively, over 6 months, and were similar in both groups. In addition, CD4 and CD8 lymphocyte counts, viraemia, tumour necrosis factor soluble receptors remained statistically unchanged and were similar in both groups. CONCLUSIONS: Enrichment of an oral nutritive supplement with arginine and omega-3 fatty acids did not improve immunological parameters. However, body weight increased in both groups.
Keywords Acquired Immunodeficiency Syndrome/diagnosisAdultArginine/administration & dosage/ therapeutic useBody CompositionBody WeightCD4 Lymphocyte CountCD8-Positive T-Lymphocytes/immunologyDietary SupplementsDouble-Blind MethodEatingElectric ImpedanceFatty Acids, Omega-3/administration & dosage/ therapeutic useFeeding BehaviorFemaleHIV Infections/diagnosis/ diet therapy/immunologyHumansLymphocyte CountMaleMinerals/administration & dosageOutpatientsPatient ComplianceQuality of LifeReceptors, Tumor Necrosis Factor/analysis/metabolismViremia/diagnosis/metabolismVitamins/administration & dosageWeight Gain
Identifiers
PMID: 9456255
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PICHARD, Claude et al. A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and omega-3 fatty acids in HIV-infected patients. Swiss HIV Cohort Study. In: AIDS, 1998, vol. 12, n° 1, p. 53-63. https://archive-ouverte.unige.ch/unige:7476

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Deposited on : 2010-06-21

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