Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes

Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; Buehler, Leo Hans; Maechler, Pierre; Dermitzakis, Emmanouil; Neerman Arbez, Marguerite

doi:10.1016/j.dib.2015.05.023

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Title		Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes
Authors		Lukowski, Samuel Fish, Richard Martin-Levilain, Juliette Gonelle-Gispert, Carmen Buehler, Leo Hans Maechler, Pierre Dermitzakis, Emmanouil Neerman Arbez, Marguerite
Published in		Data in brief. 2015, vol. 4, p. 226-8
Abstract		Understanding the interactions between miRNAs and genes they regulate during the acute phase response is crucial to our understanding of inflammatory diseases and processes. Inducing the acute phase response in hepatocytes by stimulating them with interleukin-6 [1] and then examining global changes in mRNA and miRNA expression can provide insight into the timing and dynamics of these interactions. Here we provide additional data for our study, Ref. [2]. In this data, we identify and validate IL-6-induced changes in gene expression [3-6] and their functional relationships over time and between cell types by gene ontology [7,8]. We also provide data showing the enrichment of miRNA binding motifs in the 3׳UTRs of differentially expressed genes [9], and their predicted gene targets derived from our RNA-seq data [10].
Identifiers		DOI: 10.1016/j.dib.2015.05.023 PMID: 26217794
Full text		Article (Published version) (170 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Cultures cellulaires et transplantations (519) Mitochondries et sécrétion d'insuline (671) Population Genomics and Genetics of Complex Traits (892) Recherche translationnelle : anomalies de l'hémostase et thromboses (504)
Citation (ISO format)		LUKOWSKI, Samuel et al. Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes. In: Data in Brief, 2015, vol. 4, p. 226-8. doi: 10.1016/j.dib.2015.05.023 https://archive-ouverte.unige.ch/unige:74638