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Title

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes
Authors
Lukowski, Samuel
Fish, Richard
Martin-Levilain, Juliette
Gonelle-Gispert, Carmen
Buehler, Leo Hans
Maechler, Pierre
Dermitzakis, Emmanouil
Neerman Arbez, Marguerite
Published in Data in Brief. 2015, vol. 4, p. 226-8
Abstract Understanding the interactions between miRNAs and genes they regulate during the acute phase response is crucial to our understanding of inflammatory diseases and processes. Inducing the acute phase response in hepatocytes by stimulating them with interleukin-6 [1] and then examining global changes in mRNA and miRNA expression can provide insight into the timing and dynamics of these interactions. Here we provide additional data for our study, Ref. [2]. In this data, we identify and validate IL-6-induced changes in gene expression [3-6] and their functional relationships over time and between cell types by gene ontology [7,8]. We also provide data showing the enrichment of miRNA binding motifs in the 3׳UTRs of differentially expressed genes [9], and their predicted gene targets derived from our RNA-seq data [10].
Identifiers
PMID: 26217794
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Article (Published version) (170 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups Cultures cellulaires et transplantations (519)
Mitochondries et sécrétion d'insuline (671)
Population Genomics and Genetics of Complex Traits (892)
Bases moléculaires des anomalies génétiques de l'hémostase (504)
Citation
(ISO format) 		LUKOWSKI, Samuel et al. Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes. In: Data in Brief, 2015, vol. 4, p. 226-8. https://archive-ouverte.unige.ch/unige:74638

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Deposited on : 2015-08-11

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