PM
Maechler, Pierre
| Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
|---|---|---|---|---|---|---|---|
| Hepatoprotective role for ERMP1 in MASLD-driven hepatocarcinogenesis and β-catenin-mutated tumors | Cancer letters | 2026 | 1 | 0 | |||
| The bottleneck of fat burning | Science | 2026 | 8 | 0 | |||
| TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s disease | Journal of neuroinflammation | 2025 | 30 | 20 | |||
| Comparative analysis of S100A10 and S100A11 in MASLD and hepatic cancer development revealed a tumor suppressive role for S100A10 | Cell death and disease | 2025 | 38 | 14 | |||
| ERMP1 as a newly identified ER stress gatekeeper in chronic kidney disease | American journal of physiology. Renal physiology | 2025 | 113 | 123 | |||
| In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion | The Journal of biological chemistry | 2025 | 50 | 46 | |||
| Dietary protein load affects the energy and nitrogen balance requiring liver glutamate dehydrogenase to maintain physical activity | The Journal of biological chemistry | 2024 | 108 | 37 | |||
| GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels | Developmental cell | 2024 | 143 | 125 | |||
| Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release | Diabetes | 2024 | 367 | 3 | |||
| Role of fatty acids in the pathogenesis of ß-cell failure and Type-2 diabetes | Atherosclerosis | 2024 | 90 | 119 | |||
| The Effect of a Lipid Surface Coating on the Permeation of Upconverting Nanoparticles through a 3D Human Lung Epithelial Model | Advanced functional materials | 2023 | 199 | 51 | |||
| Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes | Biochimica et biophysica acta. G, General subjects | 2023 | 94 | 0 | |||
| Circulating 1,5-anhydroglucitol as a biomarker of ß-cell mass independent of a diabetes phenotype in human subjects | The Journal of clinical endocrinology and metabolism | 2022 | 418 | 2 | |||
| Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity | Scientific reports | 2022 | 229 | 171 | |||
| Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells | Diabetologia | 2022 | 234 | 1 | |||
| Lipid-induced adaptations of the pancreatic beta-cell to glucotoxic conditions sustain insulin secretion | International journal of molecular sciences | 2021 | 178 | 206 | |||
| Glutamate dehydrogenase is important for ammonia fixation and amino acid homeostasis in brain during hyperammonemia | Frontiers in Neuroscience | 2021 | 631 | 221 | |||
| Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα | Nature communications | 2021 | 284 | 234 | |||
| Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation | Nature metabolism | 2021 | 265 | 180 | |||
| Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling | Biochimica et Biophysica Acta - Molecular Cell Research | 2020 | 566 | 8 | |||
| Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase | Human Genomics | 2020 | 479 | 290 | |||
| Macrophage-derived glutamine boosts satellite cells and muscle regeneration | Nature | 2020 | 312 | 1 | |||
| AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics | Glia | 2020 | 395 | 8 | |||
| Mitochondrial carriers regulating insulin secretion profiled in human islets upon metabolic stress | Biomolecules | 2020 | 242 | 77 | |||
| AMPK profiling in rodent and human pancreatic beta-cells under nutrient-rich metabolic stress | International Journal of Molecular Sciences | 2020 | 342 | 200 | |||
| In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way | Journal of Biological Chemistry | 2019 | 457 | 152 | |||
| L'exposition des cellules bêta au fructose potentialise la sécrétion d'insuline via une signalisation par l'ATP | Revue médicale suisse | 2019 | 466 | 213 | |||
| Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling | American Journal of Physiology. Endocrinology and Metabolism | 2019 | 841 | 1,257 | |||
| Reply to Mishra: prohibitin heterodimers—a complex time dependence for carcinogenesis | Journal of Biological Chemistry | 2019 | 317 | 124 | |||
| Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion | Pflügers Archiv | 2019 | 398 | 3 | |||
| Metabolomics identifies a biomarker revealing in vivo loss of functional ß-cell mass before diabetes onset | Diabetes | 2019 | 388 | 1,036 | |||
| Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction | Schizophrenia Bulletin | 2019 | 385 | 0 | |||
| Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation | Journal of Cerebral Blood Flow and Metabolism | 2018 | 571 | 3 | |||
| Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis | Diabetes | 2018 | 414 | 887 | |||
| Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia | Human Molecular Genetics | 2017 | 565 | 10 | |||
| Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions | Journal of Physiology and Pharmacology | 2017 | 486 | 1 | |||
| Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production | Immunity | 2017 | 570 | 0 | |||
| Glutamate pathways of the beta-cell and the control of insulin secretion | Diabetes Research and Clinical Practice | 2017 | 508 | 588 | |||
| Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity | Redox Biology | 2017 | 489 | 208 | |||
| Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression | Diabetes | 2017 | 582 | 1 | |||
| Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state? | The International Journal of Biochemistry & Cell Biology | 2017 | 1,895 | 1,397 | |||
| Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells | Cell reports | 2016 | 528 | 126 | |||
| Beta-cell mitochondrial carriers and the diabetogenic stress response | Biochimica et biophysica acta | 2016 | 495 | 575 | |||
| Activation of nicotinic acetylcholine receptors decreases apoptosis in human and female murine pancreatic islets | Endocrinology | 2016 | 580 | 315 | |||
| The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity | The Journal of biological chemistry | 2016 | 615 | 201 | |||
| Channels and transporters in cell metabolism | Biochimica et biophysica acta | 2016 | 529 | 1 | |||
| Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs? | Nature medicine | 2015 | 618 | 0 | |||
| Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells | Biochimica et biophysica acta | 2015 | 657 | 4 | |||
| Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes | Genomics | 2015 | 644 | 4 | |||
| GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution | Cell reports | 2015 | 635 | 315 | |||
| Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets | Human molecular genetics | 2015 | 717 | 341 | |||
| Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes | Data in brief | 2015 | 693 | 319 | |||
| A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets | Journal of proteomics | 2014 | 607 | 0 | |||
| Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB | The Journal of nutritional biochemistry | 2013 | 599 | 0 | |||
| Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids | PloS one | 2013 | 747 | 448 | |||
| Hepatic glucose sensing is required to preserve β cell glucose competence | The Journal of clinical investigation | 2013 | 739 | 826 | |||
| Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development | Diabetes | 2013 | 655 | 3 | |||
| Mitochondrial function and insulin secretion | Molecular and cellular endocrinology | 2013 | 602 | 0 | |||
| Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E | Acta diabetologica | 2013 | 658 | 0 | |||
| Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter | Neurochemical research | 2013 | 679 | 3 | |||
| NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion | Diabetes | 2012 | 821 | 557 | |||
| Mitochondrial dysfunction in pancreatic β cells | Trends in endocrinology and metabolism | 2012 | 591 | 4 | |||
| Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission | Journal of neurochemistry | 2012 | 695 | 463 | |||
| Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role? | Oxidative medicine and cellular longevity | 2012 | 683 | 522 | |||
| Mitochondrial signal transduction in pancreatic β-cells | Baillière's best practice & research. Clinical endocrinology & metabolism | 2012 | 548 | 0 | |||
| Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase | Molecular biology of the cell | 2012 | 697 | 371 | |||
| Mitochondria in endocrinology | Baillière's best practice & research. Clinical endocrinology & metabolism | 2012 | 615 | 0 | |||
| Procyanidins modify insulinemia by affecting insulin production and degradation | The Journal of nutritional biochemistry | 2012 | 657 | 0 | |||
| ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells | The Journal of biological chemistry | 2011 | 637 | 0 | |||
| Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism | The Journal of biological chemistry | 2011 | 653 | 1 | |||
| Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis | Aging | 2011 | 628 | 0 | |||
| Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats | Current pharmaceutical biotechnology | 2011 | 567 | 0 | |||
| From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis | Neurochemistry international | 2011 | 648 | 3 | |||
| A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes | Nutrition & metabolism | 2011 | 628 | 181 | |||
| Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells | Medicinal chemistry | 2011 | 557 | 0 | |||
| Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells | Acta Biochimica Polonica | 2011 | 563 | 0 | |||
| Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells | Journal of cellular physiology | 2010 | 612 | 0 | |||
| Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism | Diabetologia | 2010 | 824 | 129 | |||
| PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction | Journal of lipid research | 2010 | 630 | 1 | |||
| Minireview: new roles for peripheral dopamine on metabolic control and tumor growth: let's seek the balance | Endocrinology | 2010 | 581 | 0 | |||
| The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells | Biochemical pharmacology | 2010 | 629 | 0 | |||
| Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on beta-cells by enhancing glucose-stimulated insulin secretion | Journal of Endocrinology | 2010 | 685 | 0 | |||
| Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells | The Journal of biological chemistry | 2010 | 711 | 1 | |||
| Role of mitochondria in beta-cell function and dysfunction | Advances in experimental medicine and biology | 2010 | 645 | 0 | |||
| Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction | The Journal of biological chemistry | 2009 | 515 | 692 | |||
| Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion | The Journal of biological chemistry | 2009 | 613 | 1 | |||
| Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets | Biochemical journal | 2009 | 693 | 0 | |||
| Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia | Molecular pain | 2009 | 763 | 871 | |||
| Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis | The Journal of biological chemistry | 2009 | 562 | 0 | |||
| Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism | Clinical science | 2009 | 648 | 0 | |||
| The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress | Biochemical Society transactions | 2008 | 559 | 0 | |||
| Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA | PloS one | 2008 | 740 | 432 | |||
| Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis | Biochimica et biophysica acta | 2008 | 622 | 0 | |||
| Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells | Diabetologia | 2008 | 678 | 0 | |||
| Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells | Endocrinology | 2004 | 467 | 0 | |||
| Islet β-cell secretion determines glucagon release from neighbouring α-cells | Nature cell biology | 2003 | 622 | 0 | |||
| Mitochondria respond to Ca2+ already in the submicromolar range: correlation with redox state | Cell calcium | 2002 | 600 | 695 | |||
| Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites | Diabetes | 2002 | 541 | 365 | |||
| Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation | The Journal of biological chemistry | 2001 | 662 | 1,692 | |||
| GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells | The Journal of biological chemistry | 2001 | 570 | 269 | |||
| Mitochondrial calcium oscillations in C2C12 myotubes | The Journal of biological chemistry | 2001 | 582 | 0 | |||
| Mitochondrial function in normal and diabetic beta-cells | Nature | 2001 | 598 | 1,053 | |||
| Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells | IUBMB life | 2000 | 602 | 334 | |||
| Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion | The Journal of biological chemistry | 2000 | 649 | 322 | |||
| Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell | Journal of physiology | 2000 | 539 | 471 | |||
| Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells | The Journal of biological chemistry | 1999 | 605 | 475 | |||
| Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis | Nature | 1999 | 698 | 596 | |||
| Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger | Journal of cell science | 1999 | 594 | 359 | |||
| Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell | BioFactors | 1998 | 524 | 376 | |||
| Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line | EMBO journal | 1998 | 600 | 377 | |||
| Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell | The Journal of biological chemistry | 1998 | 643 | 260 |
