PM
Maechler, Pierre
| Title | Published in | Access level | OA Policy | Year | Views | Downloads | |
|---|---|---|---|---|---|---|---|
| TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s disease | Journal of neuroinflammation |  | 2025 | 11 | 7 | ||
| Comparative analysis of S100A10 and S100A11 in MASLD and hepatic cancer development revealed a tumor suppressive role for S100A10 | Cell death and disease | | 2025 | 27 | 8 | ||
| ERMP1 as a newly identified ER stress gatekeeper in chronic kidney disease | American journal of physiology. Renal physiology | | 2025 | 106 | 107 | ||
| In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion | The Journal of biological chemistry | | 2025 | 42 | 31 | ||
| Dietary protein load affects the energy and nitrogen balance requiring liver glutamate dehydrogenase to maintain physical activity | The Journal of biological chemistry | | 2024 | 104 | 31 | ||
| GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels | Developmental cell | | 2024 | 137 | 93 | ||
| Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release | Diabetes |  | 2024 | 363 | 3 | ||
| Role of fatty acids in the pathogenesis of ß-cell failure and Type-2 diabetes | Atherosclerosis | | 2024 | 85 | 78 | ||
| The Effect of a Lipid Surface Coating on the Permeation of Upconverting Nanoparticles through a 3D Human Lung Epithelial Model | Advanced functional materials | | 2023 | 194 | 46 | ||
| Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes | Biochimica et biophysica acta. G, General subjects | | 2023 | 92 | 0 | ||
| Circulating 1,5-anhydroglucitol as a biomarker of ß-cell mass independent of a diabetes phenotype in human subjects | Journal of clinical endocrinology & metabolism | | 2022 | 414 | 2 | ||
| Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity | Scientific reports | | 2022 | 226 | 129 | ||
| Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells | Diabetologia | | 2022 | 228 | 1 | ||
| Lipid-induced adaptations of the pancreatic beta-cell to glucotoxic conditions sustain insulin secretion | International journal of molecular sciences | | 2021 | 176 | 178 | ||
| Glutamate dehydrogenase is important for ammonia fixation and amino acid homeostasis in brain during hyperammonemia | Frontiers in Neuroscience | | 2021 | 627 | 133 | ||
| Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα | Nature communications | | 2021 | 280 | 205 | ||
| Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation | Nature metabolism | | 2021 | 259 | 163 | ||
| Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling | Biochimica et Biophysica Acta - Molecular Cell Research | | 2020 | 562 | 8 | ||
| Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase | Human Genomics | | 2020 | 477 | 254 | ||
| Macrophage-derived glutamine boosts satellite cells and muscle regeneration | Nature | | 2020 | 309 | 1 | ||
| AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics | Glia | | 2020 | 385 | 8 | ||
| Mitochondrial carriers regulating insulin secretion profiled in human islets upon metabolic stress | Biomolecules | | 2020 | 238 | 72 | ||
| AMPK profiling in rodent and human pancreatic beta-cells under nutrient-rich metabolic stress | International Journal of Molecular Sciences | | 2020 | 339 | 182 | ||
| In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way | Journal of Biological Chemistry | | 2019 | 456 | 137 | ||
| L'exposition des cellules bêta au fructose potentialise la sécrétion d'insuline via une signalisation par l'ATP | Revue médicale suisse | | 2019 | 464 | 197 | ||
| Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling | American Journal of Physiology. Endocrinology and Metabolism | | 2019 | 837 | 1,170 | ||
| Reply to Mishra: prohibitin heterodimers—a complex time dependence for carcinogenesis | Journal of Biological Chemistry | | 2019 | 315 | 107 | ||
| Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion | Pflügers Archiv | | 2019 | 397 | 3 | ||
| Metabolomics identifies a biomarker revealing in vivo loss of functional ß-cell mass before diabetes onset | Diabetes | | 2019 | 379 | 1,014 | ||
| Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction | Schizophrenia Bulletin | | 2019 | 383 | 0 | ||
| Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation | Journal of Cerebral Blood Flow and Metabolism | | 2018 | 569 | 3 | ||
| Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis | Diabetes | | 2018 | 412 | 715 | ||
| Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia | Human Molecular Genetics | | 2017 | 560 | 10 | ||
| Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions | Journal of Physiology and Pharmacology | | 2017 | 485 | 1 | ||
| Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production | Immunity | | 2017 | 568 | 0 | ||
| Glutamate pathways of the beta-cell and the control of insulin secretion | Diabetes Research and Clinical Practice | | 2017 | 504 | 543 | ||
| Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity | Redox Biology | | 2017 | 487 | 200 | ||
| Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression | Diabetes | | 2017 | 577 | 1 | ||
| Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state? | The International Journal of Biochemistry & Cell Biology | | 2017 | 1,886 | 1,237 | ||
| Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells | Cell reports | | 2016 | 525 | 122 | ||
| Beta-cell mitochondrial carriers and the diabetogenic stress response | Biochimica et biophysica acta | | 2016 | 491 | 501 | ||
| Activation of nicotinic acetylcholine receptors decreases apoptosis in human and female murine pancreatic islets | Endocrinology | | 2016 | 577 | 272 | ||
| The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity | The Journal of biological chemistry | | 2016 | 610 | 196 | ||
| Channels and transporters in cell metabolism | Biochimica et biophysica acta | | 2016 | 526 | 1 | ||
| Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs? | Nature medicine | | 2015 | 615 | 0 | ||
| Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells | Biochimica et biophysica acta | | 2015 | 654 | 4 | ||
| Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes | Genomics | | 2015 | 642 | 4 | ||
| GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution | Cell reports | | 2015 | 634 | 296 | ||
| Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets | Human molecular genetics | | 2015 | 715 | 330 | ||
| Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes | Data in brief | | 2015 | 691 | 290 | ||
| A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets | Journal of proteomics | | 2014 | 604 | 0 | ||
| Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB | The Journal of nutritional biochemistry | | 2013 | 596 | 0 | ||
| Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids | PloS one | | 2013 | 745 | 439 | ||
| Hepatic glucose sensing is required to preserve β cell glucose competence | The Journal of clinical investigation | | 2013 | 734 | 789 | ||
| Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development | Diabetes | | 2013 | 650 | 3 | ||
| Mitochondrial function and insulin secretion | Molecular and cellular endocrinology | | 2013 | 599 | 0 | ||
| Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E | Acta diabetologica | | 2013 | 647 | 0 | ||
| Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter | Neurochemical research | | 2013 | 677 | 3 | ||
| NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion | Diabetes | | 2012 | 814 | 532 | ||
| Mitochondrial dysfunction in pancreatic β cells | Trends in endocrinology and metabolism | | 2012 | 588 | 4 | ||
| Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission | Journal of neurochemistry | | 2012 | 691 | 443 | ||
| Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role? | Oxidative medicine and cellular longevity | | 2012 | 680 | 507 | ||
| Mitochondrial signal transduction in pancreatic β-cells | Baillière's best practice & research. Clinical endocrinology & metabolism | | 2012 | 545 | 0 | ||
| Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase | Molecular biology of the cell | | 2012 | 690 | 349 | ||
| Mitochondria in endocrinology | Baillière's best practice & research. Clinical endocrinology & metabolism | | 2012 | 608 | 0 | ||
| Procyanidins modify insulinemia by affecting insulin production and degradation | The Journal of nutritional biochemistry | | 2012 | 652 | 0 | ||
| ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells | The Journal of biological chemistry | | 2011 | 633 | 0 | ||
| Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism | The Journal of biological chemistry | | 2011 | 650 | 1 | ||
| Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis | Aging | | 2011 | 626 | 0 | ||
| Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats | Current pharmaceutical biotechnology | 2011 | 560 | 0 | |||
| From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis | Neurochemistry international | | 2011 | 645 | 3 | ||
| A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes | Nutrition & metabolism | | 2011 | 622 | 173 | ||
| Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells | Medicinal chemistry | 2011 | 555 | 0 | |||
| Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells | Acta Biochimica Polonica | | 2011 | 558 | 0 | ||
| Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells | Journal of cellular physiology | | 2010 | 608 | 0 | ||
| Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism | Diabetologia | | 2010 | 819 | 121 | ||
| PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction | Journal of lipid research | | 2010 | 627 | 1 | ||
| Minireview: new roles for peripheral dopamine on metabolic control and tumor growth: let's seek the balance | Endocrinology | | 2010 | 575 | 0 | ||
| The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells | Biochemical pharmacology | | 2010 | 626 | 0 | ||
| Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on beta-cells by enhancing glucose-stimulated insulin secretion | Journal of Endocrinology | | 2010 | 680 | 0 | ||
| Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells | The Journal of biological chemistry | | 2010 | 707 | 1 | ||
| Role of mitochondria in beta-cell function and dysfunction | Advances in experimental medicine and biology | 2010 | 641 | 0 | |||
| Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction | The Journal of biological chemistry | | 2009 | 509 | 671 | ||
| Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion | The Journal of biological chemistry | | 2009 | 607 | 1 | ||
| Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets | Biochemical journal | | 2009 | 685 | 0 | ||
| Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia | Molecular pain | | 2009 | 759 | 859 | ||
| Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis | The Journal of biological chemistry | | 2009 | 558 | 0 | ||
| Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism | Clinical science | | 2009 | 640 | 0 | ||
| The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress | Biochemical Society transactions | | 2008 | 555 | 0 | ||
| Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA | PloS one | | 2008 | 735 | 421 | ||
| Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis | Biochimica et biophysica acta | | 2008 | 619 | 0 | ||
| Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells | Diabetologia | | 2008 | 673 | 0 | ||
| Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells | Endocrinology | | 2004 | 465 | 0 | ||
| Islet β-cell secretion determines glucagon release from neighbouring α-cells | Nature cell biology | | 2003 | 615 | 0 | ||
| Mitochondria respond to Ca2+ already in the submicromolar range: correlation with redox state | Cell calcium | | 2002 | 596 | 659 | ||
| Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites | Diabetes | | 2002 | 538 | 293 | ||
| Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation | The Journal of biological chemistry | | 2001 | 658 | 1,658 | ||
| GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells | The Journal of biological chemistry | | 2001 | 568 | 242 | ||
| Mitochondrial calcium oscillations in C2C12 myotubes | The Journal of biological chemistry | | 2001 | 579 | 0 | ||
| Mitochondrial function in normal and diabetic beta-cells | Nature | | 2001 | 596 | 979 | ||
| Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells | IUBMB life | | 2000 | 598 | 312 | ||
| Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion | The Journal of biological chemistry | | 2000 | 647 | 307 | ||
| Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell | Journal of physiology | | 2000 | 535 | 415 | ||
| Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells | The Journal of biological chemistry | | 1999 | 598 | 426 | ||
| Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis | Nature | | 1999 | 694 | 572 | ||
| Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger | Journal of cell science | | 1999 | 590 | 333 | ||
| Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell | BioFactors | | 1998 | 519 | 349 | ||
| Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line | EMBO journal | | 1998 | 596 | 351 | ||
| Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell | The Journal of biological chemistry | | 1998 | 639 | 240 |
