Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS

Berscheid, Anne; Francois, Patrice; Strittmatter, Axel; Gottschalk, Gerhard; Schrenzel, Jacques; Sass, Peter; Bierbaum, Gabriele

doi:10.1093/jac/dku297

Scientific article

English

Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS

ContributorsBerscheid, Anne; Francois, Patrice

; Strittmatter, Axel; Gottschalk, Gerhard; Schrenzel, Jacques; Sass, Peter; Bierbaum, Gabriele

Published inThe journal of antimicrobial chemotherapy, vol. 69, no. 12, p. 3190-3198

Publication date2014

Abstract

Staphylococcus aureus is a notorious bacterial pathogen and antibiotic-resistant isolates complicate current treatment strategies. We characterized S. aureus VC40, a laboratory mutant that shows full resistance to glycopeptides (vancomycin and teicoplanin MICs ≥32 mg/L) and daptomycin (MIC = 4 mg/L), to gain deeper insights into the underlying resistance mechanisms.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Génomique et microbiote (604)

Citation (ISO format)

BERSCHEID, Anne et al. Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS. In: The journal of antimicrobial chemotherapy, 2014, vol. 69, n° 12, p. 3190–3198. doi: 10.1093/jac/dku297

Article (Published version)

Identifiers

PID : unige:74125
DOI : 10.1093/jac/dku297
PMID : 25103491

Journal ISSN0305-7453

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Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS

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