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Title

Fulminant atypical Cryptococcus neoformans pneumonia confirmed by PLEX-ID.
Authors
Gariani, Karim
Rougemont, Mathieu
Renzi, Gesuele
Hibbs, Jonathan
Emonet, Stéphane Paul
Schrenzel, Jacques
Published in International Journal of Infectious Diseases. 2014, vol. 22, p. 17-8
Abstract Use of the PLEX-ID system can lead to a rapid molecular diagnosis in microbiology. To illustrate the clinical implications of this new diagnostic tool, we present the case of a 46-year-old patient admitted with severe respiratory failure and septic shock. Cryptococcal pneumonia was diagnosed by Fungi-Fluor™ staining of the bronchoalveolar lavage (BAL) and the patient tested positive for HIV. Unfortunately, he died 12h after admission despite intensive care support and treatment with broad-spectrum antibiotics, amphotericin B, and flucytosine. Retrospective use of the PLEX-ID on the BAL, bronchial aspirate, and blood yielded Cryptococcus neoformans in all fluids tested. Rapid molecular diagnosis with PLEX-ID, especially when performed on the blood of septic patients, may reduce the time to adequate treatment and limit the number of diagnostic procedures needed.
Keywords Amphotericin B/therapeutic use — Anti-Bacterial Agents/therapeutic use — Antifungal Agents/therapeutic use — Bronchoalveolar Lavage Fluid/microbiology — Coinfection — Cryptococcosis/diagnosis/drug therapy/microbiology/pathology — Cryptococcus neoformans/genetics/isolation & purification — Fatal Outcome — Female — Flucytosine/therapeutic use — HIV Infections/diagnosis/pathology/virology — Humans — Male — Middle Aged — Nucleic Acid Amplification Techniques — Pneumonia/diagnosis/drug therapy/microbiology/pathology
Identifiers
PMID: 24589681
Full text
Article (Published version) (411 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
Citation
(ISO format) 		GARIANI, Karim et al. Fulminant atypical Cryptococcus neoformans pneumonia confirmed by PLEX-ID. In: International Journal of Infectious Diseases, 2014, vol. 22, p. 17-8. https://archive-ouverte.unige.ch/unige:74112

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Deposited on : 2015-07-14

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