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Title

Fulminant atypical Cryptococcus neoformans pneumonia confirmed by PLEX-ID.

Authors
Hibbs, Jonathan
Published in International Journal of Infectious Diseases. 2014, vol. 22, p. 17-8
Abstract Use of the PLEX-ID system can lead to a rapid molecular diagnosis in microbiology. To illustrate the clinical implications of this new diagnostic tool, we present the case of a 46-year-old patient admitted with severe respiratory failure and septic shock. Cryptococcal pneumonia was diagnosed by Fungi-Fluor™ staining of the bronchoalveolar lavage (BAL) and the patient tested positive for HIV. Unfortunately, he died 12h after admission despite intensive care support and treatment with broad-spectrum antibiotics, amphotericin B, and flucytosine. Retrospective use of the PLEX-ID on the BAL, bronchial aspirate, and blood yielded Cryptococcus neoformans in all fluids tested. Rapid molecular diagnosis with PLEX-ID, especially when performed on the blood of septic patients, may reduce the time to adequate treatment and limit the number of diagnostic procedures needed.
Keywords Amphotericin B/therapeutic useAnti-Bacterial Agents/therapeutic useAntifungal Agents/therapeutic useBronchoalveolar Lavage Fluid/microbiologyCoinfectionCryptococcosis/diagnosis/drug therapy/microbiology/pathologyCryptococcus neoformans/genetics/isolation & purificationFatal OutcomeFemaleFlucytosine/therapeutic useHIV Infections/diagnosis/pathology/virologyHumansMaleMiddle AgedNucleic Acid Amplification TechniquesPneumonia/diagnosis/drug therapy/microbiology/pathology
Identifiers
PMID: 24589681
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Article (Published version) (411 Kb) - public document Free access
Structures
Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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(ISO format)
GARIANI, Karim et al. Fulminant atypical Cryptococcus neoformans pneumonia confirmed by PLEX-ID. In: International Journal of Infectious Diseases, 2014, vol. 22, p. 17-8. https://archive-ouverte.unige.ch/unige:74112

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Deposited on : 2015-07-14

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