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Title

Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis

Authors
Cramton, S. E.
Gotz, Friedrich
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Published in FEMS Immunology and Medical Microbiology. 2003, vol. 35, no. 2, p. 135-140
Abstract The contribution of in vivo biofilm-forming potential of Staphylococcus aureus and Staphylococcus epidermidis was studied in an experimental model of foreign body infections. Increasing inocula (from 10(2) to 10(7) organisms) of ica-positive strains of S. aureus and S. epidermidis and their ica-negative isogenic mutants (the ica locus codes for a major polysaccharide component of biofilm) were injected into subcutaneously implanted tissue cages in guinea pigs. Surprisingly, bacterial counts and time-course of tissue cage infection by ica-positive strains of S. aureus or S. epidermidis were equivalent to those of their respective ica-negative mutants, in the locally infected fluids and on tissue-cage-inserted plastic coverslips.
Keywords AnimalsBiofilmsDisease Models, AnimalForeign Bodies/ complicationsGuinea PigsStaphylococcal Infections/ etiologyStaphylococcus aureus/ pathogenicityStaphylococcus epidermidis/ pathogenicity
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PMID: 12628549
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FRANCOIS, Patrice et al. Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis. In: FEMS Immunology and Medical Microbiology, 2003, vol. 35, n° 2, p. 135-140. https://archive-ouverte.unige.ch/unige:7232

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Deposited on : 2010-06-21

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