Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis

Francois, Patrice; Tu Quoc, Patrick Hung; Bisognano, Carmelo; Kelley, William; Lew, Daniel Pablo; Schrenzel, Jacques; Cramton, S. E.; Gotz, Friedrich; Vaudaux, Pierre

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis
Authors		Francois, Patrice Tu Quoc, Patrick Hung Bisognano, Carmelo Kelley, William Lew, Daniel Pablo Schrenzel, Jacques Cramton, S. E. Gotz, Friedrich Vaudaux, Pierre show all authors [1 - 9]
Published in		FEMS Immunology and Medical Microbiology. 2003, vol. 35, no. 2, p. 135-140
Abstract		The contribution of in vivo biofilm-forming potential of Staphylococcus aureus and Staphylococcus epidermidis was studied in an experimental model of foreign body infections. Increasing inocula (from 10(2) to 10(7) organisms) of ica-positive strains of S. aureus and S. epidermidis and their ica-negative isogenic mutants (the ica locus codes for a major polysaccharide component of biofilm) were injected into subcutaneously implanted tissue cages in guinea pigs. Surprisingly, bacterial counts and time-course of tissue cage infection by ica-positive strains of S. aureus or S. epidermidis were equivalent to those of their respective ica-negative mutants, in the locally infected fluids and on tissue-cage-inserted plastic coverslips.
Keywords		Animals — Biofilms — Disease Models, Animal — Foreign Bodies/ complications — Guinea Pigs — Staphylococcal Infections/ etiology — Staphylococcus aureus/ pathogenicity — Staphylococcus epidermidis/ pathogenicity
Identifiers		PMID: 12628549
Full text		Article - Limited access to UNIGE Other version: http://www3.interscience.wiley.com/cgi-bin/fulltext/118887554/PDFSTART
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Citation (ISO format)		FRANCOIS, Patrice et al. Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis. In: FEMS Immunology and Medical Microbiology, 2003, vol. 35, n° 2, p. 135-140. https://archive-ouverte.unige.ch/unige:7232