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Title

Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade

Authors
Giovannoni, Laurianne
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Published in Transplantation. 2015, vol. 99, no. 1, p. 29-35
Abstract Toll-like receptors are key players in sterile inflammation phenomena and can link the innate and adaptive immune systems by enhancing graft immunogenicity. They are also considered mediators of types 1 and 2 diabetes development. The aim of the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammatory and immune responses to pancreatic islets, thereby promoting inflammatory destruction and immune rejection of islet grafts.
Keywords AllograftsAnimalsAntibodies, Monoclonal/pharmacologyApoptosis/drug effectsCell Proliferation/drug effectsCells, CulturedGraft Rejection/immunology/prevention & controlGraft Survival/drug effectsHumansImmunologic Memory/drug effectsImmunosuppressive Agents/pharmacologyIslets of Langerhans/drug effects/immunology/pathologyIslets of Langerhans Transplantation/methodsLymphocyte Activation/drug effectsMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred DBASkin TransplantationT-Lymphocytes/drug effects/immunologyTime FactorsTissue Culture TechniquesToll-Like Receptor 4/antagonists & inhibitors/immunology
Identifiers
PMID: 25340601
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Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Transplantation et hépatologie (905)
Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
La transplantation d'îlots de Langerhans (623)
Citation
(ISO format)
GIOVANNONI, Laurianne et al. Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade. In: Transplantation, 2015, vol. 99, n° 1, p. 29-35. doi: 10.1097/TP.0000000000000468 https://archive-ouverte.unige.ch/unige:48098

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Deposited on : 2015-03-11

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