Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade

Giovannoni, Laurianne; Muller, Yannick; Lacotte, Stéphanie; Parnaud, Géraldine; Borot, Sophie; Meier, Raphaël; Lavallard, Vanessa; Bedat, Benoît; Toso, Christian; Daubeuf, Bruno; Elson, Greg; Shang, Limin; Morel, Philippe; Kosco-Vilbois, Marie; Bosco, Domenico; Berney, Thierry

doi:10.1097/TP.0000000000000468

Scientific article

English

Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade

ContributorsGiovannoni, Laurianne; Muller, Yannick; Lacotte, Stéphanie

; Parnaud, Géraldine; Borot, Sophie; Meier, Raphaël; Lavallard, Vanessa; Bedat, Benoît; Toso, Christian; Daubeuf, Bruno; Elson, Greg; Shang, Limin; Morel, Philippe; Kosco-Vilbois, Marie; Bosco, Domenico; Berney, Thierry

Published inTransplantation, vol. 99, no. 1, p. 29-35

Publication date2015

Abstract

Toll-like receptors are key players in sterile inflammation phenomena and can link the innate and adaptive immune systems by enhancing graft immunogenicity. They are also considered mediators of types 1 and 2 diabetes development. The aim of the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammatory and immune responses to pancreatic islets, thereby promoting inflammatory destruction and immune rejection of islet grafts.

Keywords

Allografts
Animals
Antibodies, Monoclonal/pharmacology
Apoptosis/drug effects
Cell Proliferation/drug effects
Cells, Cultured
Graft Rejection/immunology/prevention & control
Graft Survival/drug effects
Humans
Immunologic Memory/drug effects
Immunosuppressive Agents/pharmacology
Islets of Langerhans/drug effects/immunology/pathology
Islets of Langerhans Transplantation/methods
Lymphocyte Activation/drug effects
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Skin Transplantation
T-Lymphocytes/drug effects/immunology
Time Factors
Tissue Culture Techniques
Toll-Like Receptor 4/antagonists & inhibitors/immunology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

GIOVANNONI, Laurianne et al. Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade. In: Transplantation, 2015, vol. 99, n° 1, p. 29–35. doi: 10.1097/TP.0000000000000468

Article (Published version)

Identifiers

PID : unige:48098
DOI : 10.1097/TP.0000000000000468
PMID : 25340601

Journal ISSN0041-1337

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Creation10/03/2015 16:47:00

First validation10/03/2015 16:47:00

Update time15/03/2023 00:00:56

Status update15/03/2023 00:00:56

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Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade

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