en
Scientific article
English

Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade

Published inTransplantation, vol. 99, no. 1, p. 29-35
Publication date2015
Abstract

Toll-like receptors are key players in sterile inflammation phenomena and can link the innate and adaptive immune systems by enhancing graft immunogenicity. They are also considered mediators of types 1 and 2 diabetes development. The aim of the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammatory and immune responses to pancreatic islets, thereby promoting inflammatory destruction and immune rejection of islet grafts.

Keywords
  • Allografts
  • Animals
  • Antibodies, Monoclonal/pharmacology
  • Apoptosis/drug effects
  • Cell Proliferation/drug effects
  • Cells, Cultured
  • Graft Rejection/immunology/prevention & control
  • Graft Survival/drug effects
  • Humans
  • Immunologic Memory/drug effects
  • Immunosuppressive Agents/pharmacology
  • Islets of Langerhans/drug effects/immunology/pathology
  • Islets of Langerhans Transplantation/methods
  • Lymphocyte Activation/drug effects
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Skin Transplantation
  • T-Lymphocytes/drug effects/immunology
  • Time Factors
  • Tissue Culture Techniques
  • Toll-Like Receptor 4/antagonists & inhibitors/immunology
Citation (ISO format)
GIOVANNONI, Laurianne et al. Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade. In: Transplantation, 2015, vol. 99, n° 1, p. 29–35. doi: 10.1097/TP.0000000000000468
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1337
733views
5downloads

Technical informations

Creation03/10/2015 3:47:00 PM
First validation03/10/2015 3:47:00 PM
Update time03/14/2023 11:00:56 PM
Status update03/14/2023 11:00:56 PM
Last indexation01/16/2024 5:18:09 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack