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Scientific article
Case report
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English

Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient

Contributors

Toso, Christian; Berney, Thierry; Oberholzer, José; Chave, Jean-Philippe; Martin, Pierre-Yves; Zeender, Eve Salome; Bosco, Domenico; Morel, Philippe

Published in

American journal of transplantation, vol. 3, no. 5, p. 631-633

Publication date

2003

Abstract

With the introduction of highly active antiretroviral therapy (HAART), HIV infection has become a chronic disease with more frequent end-stage organ failures. As a result, the question of transplantation in HIV patients is raised more often. Although still subject to controversies, HIV infection is no longer an absolute contraindication to solid organ transplantation. We report a case of combined kidney-pancreas transplantation in a HIV recipient. HIV has remained stable without any antiviral therapy for up to 2 years after transplantation and has reached criteria for inclusion in the long-term nonprogressor (LTNP) group. Grafted organs demonstrated good function without rejection. This case emphasizes the need to consider LTNP HIV patients as a specific subgroup, when discussing solid organ transplantation. HAART is not required, thus sparing drug interactions and their unique immunological features, such as CCR5 mutation, might prevent rejection. This subgroup of HIV patients should be offered less restricted access to transplantation.

Keywords

  • Adult
  • Antiretroviral Therapy, Highly Active/adverse effects
  • CD4-Positive T-Lymphocytes/metabolism
  • Diabetes Mellitus, Type 1/therapy
  • Disease Progression
  • Female
  • HIV Infections/complications
  • HIV Seropositivity
  • Humans
  • Kidney Transplantation/methods
  • Pancreas Transplantation/methods
  • Pancreatic Diseases/etiology
  • Receptors, CCR5/genetics
  • Renal Insufficiency/etiology
  • Time Factors

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

TOSO, Christian et al. Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient. In: American journal of transplantation, 2003, vol. 3, n° 5, p. 631–633. doi: 10.1034/j.1600-6143.2003.00119.x

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1600-6135
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437downloads

Technical informations

Creation

15/01/2015 17:42:00

First validation

15/01/2015 17:42:00

Update

13/10/2025 21:53:40

Status update

14/03/2023 22:42:47

Last indexation

04/02/2026 14:48:55
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