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Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient

Chave, Jean-Philippe
Published in American Journal of Transplantation. 2003, vol. 3, no. 5, p. 631-3
Abstract With the introduction of highly active antiretroviral therapy (HAART), HIV infection has become a chronic disease with more frequent end-stage organ failures. As a result, the question of transplantation in HIV patients is raised more often. Although still subject to controversies, HIV infection is no longer an absolute contraindication to solid organ transplantation. We report a case of combined kidney-pancreas transplantation in a HIV recipient. HIV has remained stable without any antiviral therapy for up to 2 years after transplantation and has reached criteria for inclusion in the long-term nonprogressor (LTNP) group. Grafted organs demonstrated good function without rejection. This case emphasizes the need to consider LTNP HIV patients as a specific subgroup, when discussing solid organ transplantation. HAART is not required, thus sparing drug interactions and their unique immunological features, such as CCR5 mutation, might prevent rejection. This subgroup of HIV patients should be offered less restricted access to transplantation.
Keywords AdultAntiretroviral Therapy, Highly Active/adverse effectsCD4-Positive T-Lymphocytes/metabolismDiabetes Mellitus, Type 1/therapyDisease ProgressionFemaleHIV Infections/complicationsHIV SeropositivityHumansKidney Transplantation/methodsPancreas Transplantation/methodsPancreatic Diseases/etiologyReceptors, CCR5/geneticsRenal Insufficiency/etiologyTime Factors
PMID: 12752321
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Article (Published version) (61 Kb) - public document Free access
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
La transplantation d'îlots de Langerhans (623)
Groupe Pierre-Yves Martin (néphrologie) (30)
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TOSO, Christian et al. Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient. In: American Journal of Transplantation, 2003, vol. 3, n° 5, p. 631-3. doi: 10.1034/j.1600-6143.2003.00119.x https://archive-ouverte.unige.ch/unige:45477

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Deposited on : 2015-01-19

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