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Discovery of Sirtuin Modulators: Novel Scaffolds and Overall Strategy

Denomination Travail personnel de recherche, Master en Pharmacie
Defense Maîtrise : Univ. Genève, 2014
Abstract The members of the silent information regulator family (SIRT or Sirtuins), are evolutionarily conserved NAD dependent protein deacetylases, they are part of class III superfamily HDACs (histone deacetylase). All HDACs classes require zinc as a cofactor for catalysis whereas Sirtuins SIRT1 to 7 are dependent on NAD+ [1‐5]. The founding member of this class of deacetylases, SIRT1 (homolog of yeast silent information regulator, Sir2), is the most widely studied of the Sirtuins. Reports in yeast, nematode worms, and fruit flies described it as a promoter of stability and viability enhancer as well as lifetime extension of the organisms [6‐9].
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Research group Pharmacochimie
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KANNUNA, Ali. Discovery of Sirtuin Modulators: Novel Scaffolds and Overall Strategy. Université de Genève. Maîtrise, 2014. https://archive-ouverte.unige.ch/unige:45107

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Deposited on : 2015-01-13

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