Discovery of Sirtuin Modulators: Novel Scaffolds and Overall Strategy

ContributorsKannuna, Ali
Master program titleTravail personnel de recherche, Master en Pharmacie
Defense date2014

The members of the silent information regulator family (SIRT or Sirtuins), are evolutionarily conserved NAD dependent protein deacetylases, they are part of class III superfamily HDACs (histone deacetylase). All HDACs classes require zinc as a cofactor for catalysis whereas Sirtuins SIRT1 to 7 are dependent on NAD+ [1‐5]. The founding member of this class of deacetylases, SIRT1 (homolog of yeast silent information regulator, Sir2), is the most widely studied of the Sirtuins. Reports in yeast, nematode worms, and fruit flies described it as a promoter of stability and viability enhancer as well as lifetime extension of the organisms [6‐9].

Research group
Citation (ISO format)
KANNUNA, Ali. Discovery of Sirtuin Modulators: Novel Scaffolds and Overall Strategy. 2014.
Main files (1)
Master thesis
  • PID : unige:45107

Technical informations

Creation01/13/2015 11:18:00 AM
First validation01/13/2015 11:18:00 AM
Update time03/14/2023 10:40:03 PM
Status update03/14/2023 10:40:03 PM
Last indexation01/29/2024 8:20:23 PM
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