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ADC mapping of the aging frontal lobes in mild cognitive impairment

Wetzel, S
Kelekis, A D
Palmesino, M
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Published in Neuroradiology. 2004, vol. 46, no. 4, p. 282-6
Collection Open Access - Licence nationale Springer
Abstract Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion. We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-). In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001).
Keywords AdultAgedAged, 80 and overAging/physiologyCase-Control StudiesCognition Disorders/physiopathologyDiffusion Magnetic Resonance ImagingFemaleFrontal Lobe/pathologyHumansLeukocytesMaleMiddle Aged
PMID: 15045496
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Research groups Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) (539)
Ischémie cérébrale et connectivité (801)
Neuropsychologie et neurologie comportementale (951)
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LÖVBLAD, Karl-Olof et al. ADC mapping of the aging frontal lobes in mild cognitive impairment. In: Neuroradiology, 2004, vol. 46, n° 4, p. 282-6. doi: 10.1007/s00234-004-1183-5 https://archive-ouverte.unige.ch/unige:44942

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Deposited on : 2015-01-12

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