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Scientific article
Open access
English

ADC mapping of the aging frontal lobes in mild cognitive impairment

Published inNeuroradiology, vol. 46, no. 4, p. 282-286
Collection
  • Open Access - Licence nationale Springer
Publication date2004
Abstract

Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion. We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-). In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001).

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Case-Control Studies
  • Cognition Disorders/physiopathology
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Frontal Lobe/pathology
  • Humans
  • Leukocytes
  • Male
  • Middle Aged
Citation (ISO format)
LÖVBLAD, Karl-Olof et al. ADC mapping of the aging frontal lobes in mild cognitive impairment. In: Neuroradiology, 2004, vol. 46, n° 4, p. 282–286. doi: 10.1007/s00234-004-1183-5
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0028-3940
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