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Title

ADC mapping of the aging frontal lobes in mild cognitive impairment

Authors
Wetzel, S
Kelekis, A D
Palmesino, M
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Published in Neuroradiology. 2004, vol. 46, no. 4, p. 282-6
Abstract Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion. We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-). In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001).
Keywords AdultAgedAged, 80 and overAging/physiologyCase-Control StudiesCognition Disorders/physiopathologyDiffusion Magnetic Resonance ImagingFemaleFrontal Lobe/pathologyHumansLeukocytesMaleMiddle Aged
Identifiers
PMID: 15045496
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Structures
Research groups Ischémie cérébrale et connectivité (801)
Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) (539)
Neuropsychologie et neurologie comportementale (951)
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LÖVBLAD, Karl-Olof et al. ADC mapping of the aging frontal lobes in mild cognitive impairment. In: Neuroradiology, 2004, vol. 46, n° 4, p. 282-6. https://archive-ouverte.unige.ch/unige:44942

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Deposited on : 2015-01-12

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