ADC mapping of the aging frontal lobes in mild cognitive impairment

Article Article scientifique Article ADC mapping of the aging frontal lobes in mild cognitive impairment eng 2004 author Lövblad Karl-Olof 135154 author Delavelle Jacqueline 526549 author Wetzel S author Kelekis A D author Assal Frédéric 527005 author Palmesino M author Gold Gabriel 135308 author Yilmaz Hasan 565252 author San Millan Ruiz D author Lazeyras François 512748 author Mehdizade Mardeke Amir 81862 author Ruefenacht Daniel André 28650 282-286 10.1007/s00234-004-1183-5 15045496 0028-3940 Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion. We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-). In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001). Adult Aged Aged, 80 and over Aging/physiology Case-Control Studies Cognition Disorders/physiopathology Diffusion Magnetic Resonance Imaging Female Frontal Lobe/pathology Humans Leukocytes Male Middle Aged Dewey 616.8 Dewey 616.0757 Dewey 618.97 61 Département des neurosciences cliniques 226 62 Département de radiologie et informatique médicale 227 65 Département de réadaptation et gériatrie 22B false 312 Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive 577 284 Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) 539 470 Ischémie cérébrale et connectivité 801 928 Neuropsychologie et neurologie comportementale 951 Neuroradiology 46 4 faf32fa1-d262-4ee9-bd97-4544d39899ab Article (Published version) Public art%253A10.1007%252Fs00234-004-1183-5.pdf 950631 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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ADC mapping of the aging frontal lobes in mild cognitive impairment	Neuroradiology			2004	435	232

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Mehdizade Mardeke, Amir