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Wall shear stress distribution of small aneurysms prone to rupture: a case-control study

Published in Stroke. 2014, vol. 45, no. 1, p. 261-264
Abstract Subarachnoid hemorrhage after intracranial aneurysm rupture remains a serious condition. We performed a case-control study to evaluate the use of computed hemodynamics to detect cerebral aneurysms prone to rupture. METHODS: Four patients with incidental aneurysms that ultimately ruptured (cases) were studied after initially being included in a prospective database including their 3-dimensional imaging before rupture. Ruptures were located in different arterial segments: M1 segment of the middle cerebral artery; basilar tip; posterior inferior cerebellar artery; and anterior communicating artery. For each case, 5 controls matched by location and size were randomly selected. An empirical cumulative distribution function of aneurysm wall shear stress percentiles was evaluated for every case and used to define a critical prone-to-rupture range. Univariate logistic regression analysis was then used to assess the individual risk of rupture. RESULTS: A cumulative wall shear stress distribution characterizing a hemodynamic prone-to-rupture range for small-sized aneurysms was identified and fitted independent of the location. Sensitivity and specificity of the preliminary tests were 90% and 93%, respectively. CONCLUSIONS: The wall shear stress cumulative probability function may be a potential predictor of small-sized aneurysm rupture.
PMID: 24253545
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Research groups Ischémie cérébrale et connectivité (801)
Groupe Schaller Karl Lothard (neurochirurgie) (851)
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MENDES PEREIRA, Vitor et al. Wall shear stress distribution of small aneurysms prone to rupture: a case-control study. In: Stroke, 2014, vol. 45, n° 1, p. 261-264. https://archive-ouverte.unige.ch/unige:43949

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Deposited on : 2014-12-19

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