Scientific article
English

High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists

Published inJournal of medicinal chemistry, vol. 51, no. 3, p. 396-399
Publication date2008
Abstract

Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms.

Keywords
  • Chemistry, Pharmaceutical/methods
  • Chemistry, Physical
  • Chromatography, Liquid/methods
  • Mathematics
  • Pharmaceutical Preparations/chemistry
  • Physicochemical Phenomena
  • Software
Citation (ISO format)
HENCHOZ, Yveline et al. High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. In: Journal of medicinal chemistry, 2008, vol. 51, n° 3, p. 396–399. doi: 10.1021/jm7014809
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0022-2623
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Technical informations

Creation06/11/2009 09:18:00
First validation06/11/2009 09:18:00
Update time14/03/2023 15:17:32
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