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High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists |
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Published in | Journal of medicinal chemistry. 2008, vol. 51, no. 3, p. 396-9 | |
Abstract | Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms. | |
Keywords | Chemistry, Pharmaceutical/methods — Chemistry, Physical — Chromatography, Liquid/methods — Mathematics — Pharmaceutical Preparations/chemistry — Physicochemical Phenomena — Software | |
Identifiers | DOI: 10.1021/jm7014809 PMID: 18189348 | |
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Citation (ISO format) | HENCHOZ, Yveline et al. High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. In: Journal of medicinal chemistry, 2008, vol. 51, n° 3, p. 396-9. doi: 10.1021/jm7014809 https://archive-ouverte.unige.ch/unige:4069 |