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High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists

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Published in Journal of Medicinal Chemistry. 2008, vol. 51, no. 3, p. 396-9
Abstract Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms.
Keywords Chemistry, Pharmaceutical/methodsChemistry, PhysicalChromatography, Liquid/methodsMathematicsPharmaceutical Preparations/chemistryPhysicochemical PhenomenaSoftware
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PMID: 18189348
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HENCHOZ, Yveline et al. High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. In: Journal of Medicinal Chemistry, 2008, vol. 51, n° 3, p. 396-9. https://archive-ouverte.unige.ch/unige:4069

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Deposited on : 2009-11-20

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