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Title

Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: preliminary findings from a follow-up state-based fMRI study
Authors
Rey, Gwladys
Desseilles, Martin
Favre, Sophie
Dayer, Alexandre
Piguet, Camille Marie
Aubry, Jean-Michel
Vuilleumier, Patrik
Published in Psychiatry research. Neuroimaging. 2014, vol. 223, no. 2, p. 84-93
Abstract We used functional magnetic resonance imaging (fMRI) to examine affective control longitudinally in a group of patients with bipolar disorder (BD). Participants comprised 12 BD patients who underwent repeated fMRI scans in euthymic (n=11), depressed (n=9), or hypomanic (n=9) states, and were compared with 12 age-matched healthy controls. During fMRI, participants performed an emotional face-word interference task with either low or high attentional demands. Relative to healthy controls, patients showed decreased activation of the cognitive control network normally associated with conflict processing, more severely during hypomania than during depression, but regardless of level of task demand in both cases. During euthymia, a decreased response to conflict was observed only during the high load condition. Additionally, unlike healthy participants, patients exhibited deactivation in several key areas in response to emotion-conflict trials - including the rostral anterior cingulate cortex during euthymia, the hippocampus during depression, and the posterior cingulate cortex during hypomania. Our results indicate that the ability of BD patients to recruit control networks when processing affective conflict, and the abnormal suppression of activity in distinct components of the default mode network, may depend on their current clinical state and attentional demand.
Identifiers
PMID: 24862389
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Centres et instituts / Centre interfacultaire en sciences affectives
Research groups Affective sciences
Groupe Dayer Alexandre (Formation du circuit cortical) (875)
Mécanismes cérébraux du comportement et des fonctions cognitives (701)
Thérapeutiques des Troubles de l'Humeur et Anxieux (689)
Citation
(ISO format) 		REY, Gwladys et al. Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: preliminary findings from a follow-up state-based fMRI study. In: Psychiatry research. Neuroimaging, 2014, vol. 223, n° 2, p. 84-93. doi: 10.1016/j.pscychresns.2014.04.016 https://archive-ouverte.unige.ch/unige:40483

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Deposited on : 2014-09-24

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