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Master of advanced studies
English

Computational studies of small molecules interfering with Bcl9/β-catenin interaction as anti-colon-cancer drug candidates

Master program titleMaster en Pharmacie - Travail personel de recherche
Defense date2013
Abstract

Hyper-activation of the Wnt signaling pathway is the hallmark of colorectal cancers. This disease is also revealed by the hyperactivation of β-Catenin, which is the main transcriptional factor of this pathway. In this work the interaction between the β-Catenin and Bcl9, which a transcriptional coactivator in the Wnt pathway, is targeted to identify potential hit candidates by applying a structurebased virtual screening (VS) protocol. Initially, the potential binding modes of some active compounds (Benserazide, M2916, M0509 and M066) have been identified by two different molecular docking programs: Glide and GOLD. This could provide useful information for the discovery of potential new hits.

eng
Citation (ISO format)
BEN JANNET, Fatma Zahra. Computational studies of small molecules interfering with Bcl9/β-catenin interaction as anti-colon-cancer drug candidates. 2013.
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Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:36703
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Creation05/19/2014 10:52:00 AM
First validation05/19/2014 10:52:00 AM
Update time03/14/2023 9:14:29 PM
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