Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

Nielsen, K; Kruhøffer, M; Orntoft, T; Sparre, T; Wang, Haiyan; Wollheim, Claes; Jørgensen, M C; Nerup, J; Karlsen, A E

doi:10.1007/s00125-004-1578-1

Scientific article

English

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

ContributorsNielsen, K; Kruhøffer, M; Orntoft, T; Sparre, T; Wang, Haiyan; Wollheim, Claes; Jørgensen, M C; Nerup, J; Karlsen, A E

Published inDiabetologia, vol. 47, no. 12, p. 2185-2199

Publication date2004

Abstract

Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sensitivity to cytokines and may eventually lead to type 1 diabetes. The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure.

Keywords

Animals
Base Sequence
Cell Line
DNA Primers
Gene Expression Profiling
Gene Expression Regulation/drug effects
Homeodomain Proteins/genetics
Interleukin-1/pharmacology
Islets of Langerhans/drug effects/physiology
Islets of Langerhans Transplantation
RNA, Complementary/genetics
RNA, Messenger/genetics
Rats
Trans-Activators/genetics
Transcription, Genetic

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Citation (ISO format)

NIELSEN, K et al. Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. In: Diabetologia, 2004, vol. 47, n° 12, p. 2185–2199. doi: 10.1007/s00125-004-1578-1

Article (Published version)

Identifiers

PID : unige:34541
DOI : 10.1007/s00125-004-1578-1
PMID : 15605246

Journal ISSN0012-186X

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Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

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