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Title

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

Authors
Nielsen, K
Kruhøffer, M
Orntoft, T
Sparre, T
Jørgensen, M C
Nerup, J
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Published in Diabetologia. 2004, vol. 47, no. 12, p. 2185-99
Abstract Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sensitivity to cytokines and may eventually lead to type 1 diabetes. The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure.
Keywords AnimalsBase SequenceCell LineDNA PrimersGene Expression ProfilingGene Expression Regulation/drug effectsHomeodomain Proteins/geneticsInterleukin-1/pharmacologyIslets of Langerhans/drug effects/physiologyIslets of Langerhans TransplantationRNA, Complementary/geneticsRNA, Messenger/geneticsRatsTrans-Activators/geneticsTranscription, Genetic
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PMID: 15605246
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NIELSEN, K et al. Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. In: Diabetologia, 2004, vol. 47, n° 12, p. 2185-99. https://archive-ouverte.unige.ch/unige:34541

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Deposited on : 2014-03-03

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