Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

Nielsen, K; Kruhøffer, M; Orntoft, T; Sparre, T; Wang, Haiyan; Wollheim, Claes; Jørgensen, M C; Nerup, J; Karlsen, A E

doi:10.1007/s00125-004-1578-1

Scientific article

English

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

Contributors

Nielsen, K; Kruhøffer, M; Orntoft, T; Sparre, T; Wang, Haiyan; Wollheim, Claes; Jørgensen, M C; Nerup, J; Karlsen, A E

Published in

Diabetologia, vol. 47, no. 12, p. 2185-2199

Publication date

2004

Abstract

Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sensitivity to cytokines and may eventually lead to type 1 diabetes. The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure.

Keywords

Animals
Base Sequence
Cell Line
DNA Primers
Gene Expression Profiling
Gene Expression Regulation/drug effects
Homeodomain Proteins/genetics
Interleukin-1/pharmacology
Islets of Langerhans/drug effects/physiology
Islets of Langerhans Transplantation
RNA, Complementary/genetics
RNA, Messenger/genetics
Rats
Trans-Activators/genetics
Transcription, Genetic

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Citation (ISO format)

NIELSEN, K et al. Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. In: Diabetologia, 2004, vol. 47, n° 12, p. 2185–2199. doi: 10.1007/s00125-004-1578-1

Article (Published version)

Identifiers

PID : unige:34541
DOI : 10.1007/s00125-004-1578-1
PMID : 15605246

Journal ISSN

0012-186X

624views

214downloads

Creation

14/02/2014 11:59:00

First validation

14/02/2014 11:59:00

Update

14/03/2023 20:59:50

Status update

14/03/2023 20:59:50

Last indexation

30/10/2024 16:23:48

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation