Bacterial genome evolution within a clonal population: from in vitro investigations to in vivo observations

Beaume, Marie-Emilie; Monina, Nadezda; Schrenzel, Jacques; Francois, Patrice

doi:10.2217/fmb.13.28

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Title		Bacterial genome evolution within a clonal population: from in vitro investigations to in vivo observations
Authors		Beaume, Marie-Emilie Monina, Nadezda Schrenzel, Jacques Francois, Patrice
Published in		Future microbiology. 2013, vol. 8, no. 5, p. 661-74
Abstract		Bacteria are faced with a diversity of environmental stresses that include high salt concentrations, heavy metals and pH fluctuations. Adaptation to resist such stresses is a complex phenomenon that involves global pathways and simultaneous acquisition of multiple unrelated properties. During the last 3 years, the development of new technologies in the field of molecular biology has led to numerous fundamental and quantitative in vitro and in vivo evolutionary studies that have improved our understanding of the principles underlying bacterial adaptations, and helped us develop strategies to cope with the health burden of bacterial virulence. In this review, the authors discuss the evolution of bacteria in the laboratory and in human patients.
Keywords		Adaptation, Biological — Bacteria/genetics — Bacterial Infections/microbiology — Bacteriological Techniques — Evolution, Molecular — Genome, Bacterial — Humans — Molecular Typing
Identifiers		DOI: 10.2217/fmb.13.28 PMID: 23642119
Full text		Article (Published version) (894 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group		Analyse génomique et fonctionnelle du staphylocoque doré (604)
Citation (ISO format)		BEAUME, Marie-Emilie et al. Bacterial genome evolution within a clonal population: from in vitro investigations to in vivo observations. In: Future microbiology, 2013, vol. 8, n° 5, p. 661-74. doi: 10.2217/fmb.13.28 https://archive-ouverte.unige.ch/unige:33331