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Scientific article
Open access
English

Bacterial genome evolution within a clonal population: from in vitro investigations to in vivo observations

Published inFuture microbiology, vol. 8, no. 5, p. 661-674
Publication date2013
Abstract

Bacteria are faced with a diversity of environmental stresses that include high salt concentrations, heavy metals and pH fluctuations. Adaptation to resist such stresses is a complex phenomenon that involves global pathways and simultaneous acquisition of multiple unrelated properties. During the last 3 years, the development of new technologies in the field of molecular biology has led to numerous fundamental and quantitative in vitro and in vivo evolutionary studies that have improved our understanding of the principles underlying bacterial adaptations, and helped us develop strategies to cope with the health burden of bacterial virulence. In this review, the authors discuss the evolution of bacteria in the laboratory and in human patients.

Keywords
  • Adaptation, Biological
  • Bacteria/genetics
  • Bacterial Infections/microbiology
  • Bacteriological Techniques
  • Evolution, Molecular
  • Genome, Bacterial
  • Humans
  • Molecular Typing
Citation (ISO format)
BEAUME, Marie-Emilie et al. Bacterial genome evolution within a clonal population: from in vitro investigations to in vivo observations. In: Future microbiology, 2013, vol. 8, n° 5, p. 661–674. doi: 10.2217/fmb.13.28
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Article (Published version)
accessLevelPublic
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ISSN of the journal1746-0913
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