Impaired antibody memory to varicella zoster virus in HIV-infected children: low antibody levels and avidity*

L'Huillier, Arnaud; Ferry, T; Courvoisier, Delphine; Aebi, Christoph; Cheseaux, Jean-Jacques; Kind, C; Rudin, C; Nadal, D; Hirschel, Bernard; Sottas, Cédric Ernest; Siegrist, Claire-Anne; Posfay Barbe, Clara

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Title		Impaired antibody memory to varicella zoster virus in HIV-infected children: low antibody levels and avidity*
Authors		L'Huillier, Arnaud Ferry, T Courvoisier, Delphine Aebi, Christoph Cheseaux, Jean-Jacques Kind, C Rudin, C Nadal, D Hirschel, Bernard Sottas, Cédric Ernest Siegrist, Claire-Anne Posfay Barbe, Clara show all authors [1 - 12]
Published in		HIV Medicine. 2012, vol. 13, no. 1, p. 54-61
Abstract		HIV-infected children have impaired antibody responses after exposure to certain antigens. Our aim was to determine whether HIV-infected children had lower varicella zoster virus (VZV) antibody levels compared with HIV-infected adults or healthy children and, if so, whether this was attributable to an impaired primary response, accelerated antibody loss, or failure to reactivate the memory VZV response.
Keywords		Adolescent — Antibodies, Viral/blood/immunology — Antibody Affinity/immunology — Child — Child, Preschool — Enzyme-Linked Immunosorbent Assay — Epidemiologic Methods — Female — HIV Infections/immunology — Herpesvirus 3, Human/immunology — Humans — Immunoglobulin G/blood/immunology — Immunologic Memory/immunology — Male — Switzerland
Identifiers		DOI: 10.1111/j.1468-1293.2011.00936.x PMID: 21722287
Full text		Article (Published version) (208 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups		Centre de Vaccinologie et d'Immunologie néonatale (177) Groupe Posfay-Barbe Clara (pédiatrie générale) (853)
Citation (ISO format)		L'HUILLIER, Arnaud et al. Impaired antibody memory to varicella zoster virus in HIV-infected children: low antibody levels and avidity*. In: HIV Medicine, 2012, vol. 13, n° 1, p. 54-61. https://archive-ouverte.unige.ch/unige:31713