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Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

Li, Y
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Published in International journal of obesity. 2012, vol. 36, no. 12, p. 1503-13
Abstract NADPH oxidase 4 (NOX4) is a reactive oxygen species (ROS) producing NADPH oxidase that regulates redox homeostasis in diverse insulin-sensitive cell types. In particular, NOX4-derived ROS is a key modulator of adipocyte differentiation and mediates insulin receptor signaling in mature adipocytes in vitro. Our study was aimed at investigating the role of NOX4 in adipose tissue differentiation, whole body metabolic homeostasis and insulin sensitivity in vivo.
PMID: 22430302
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Research groups Etudes et traitement de l'hépatite C et B (554)
Génétique des Ostéoporoses (544)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
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LI, Y et al. Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity. In: International journal of obesity, 2012, vol. 36, n° 12, p. 1503-13. doi: 10.1038/ijo.2011.279 https://archive-ouverte.unige.ch/unige:27459

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Deposited on : 2013-04-10

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