Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

Li, Y; Mouche, Sarah; Sajic, Tatjana; Veyrat-Durebex, Christelle; Supale, Radhika; Pierroz Fuentes, Dominique; Ferrari, Serge Livio; Negro, Francesco; Hasler, Udo; Feraille, Eric; Moll, Solange; Meda, Paolo; Deffert, C; Montet, Xavier Cédric Rodolphe; Krause, Karl-Heinz; Szanto, Ildiko

doi:10.1038/ijo.2011.279

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Title		Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity
Authors		Li, Y Mouche, Sarah Sajic, Tatjana Veyrat-Durebex, Christelle Supale, Radhika Pierroz Fuentes, Dominique Ferrari, Serge Livio Negro, Francesco Hasler, Udo Feraille, Eric Moll, Solange Meda, Paolo Deffert, C Montet, Xavier Cédric Rodolphe Krause, Karl-Heinz Szanto, Ildiko show all authors [1 - 16]
Published in		International Journal of Obesity and Related Metabolic Disorders. 2012, vol. 36, no. 12, p. 1503-13
Abstract		NADPH oxidase 4 (NOX4) is a reactive oxygen species (ROS) producing NADPH oxidase that regulates redox homeostasis in diverse insulin-sensitive cell types. In particular, NOX4-derived ROS is a key modulator of adipocyte differentiation and mediates insulin receptor signaling in mature adipocytes in vitro. Our study was aimed at investigating the role of NOX4 in adipose tissue differentiation, whole body metabolic homeostasis and insulin sensitivity in vivo.
Identifiers		DOI: 10.1038/ijo.2011.279 PMID: 22430302
Full text		Article (Published version) (2.4 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Etudes et traitement de l'hépatite C et B (554) Génétique des Ostéoporoses (544) Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
Citation (ISO format)		LI, Y et al. Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity. In: International Journal of Obesity and Related Metabolic Disorders, 2012, vol. 36, n° 12, p. 1503-13. doi: 10.1038/ijo.2011.279 https://archive-ouverte.unige.ch/unige:27459