Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

Article Article scientifique Article Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity eng 2012 author Li Y author Mouche Sarah 103490 author Sajic Tatjana 647061 author Veyrat-Durebex Christelle 629027 author Supale Radhika 671739 author Pierroz Fuentes Dominique 28324 author Ferrari Serge Livio 24314 author Negro Francesco 96509 author Hasler Udo 134082 author Feraille Eric 27356 author Moll Solange 28349 author Meda Paolo 26346 author Deffert C author Montet Xavier Cédric Rodolphe 58743 author Krause Karl-Heinz 23022 author Szanto Ildiko 0000-0003-3566-7991 133688 1503-1513 10.1038/ijo.2011.279 22430302 0307-0565 NADPH oxidase 4 (NOX4) is a reactive oxygen species (ROS) producing NADPH oxidase that regulates redox homeostasis in diverse insulin-sensitive cell types. In particular, NOX4-derived ROS is a key modulator of adipocyte differentiation and mediates insulin receptor signaling in mature adipocytes in vitro. Our study was aimed at investigating the role of NOX4 in adipose tissue differentiation, whole body metabolic homeostasis and insulin sensitivity in vivo. Dewey 612 Dewey 616 Dewey 616.07 134 Département de physiologie cellulaire et métabolisme 21C 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 297 Etudes et traitement de l'hépatite C et B 554 289 Génétique des Ostéoporoses 544 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 International journal of obesity 36 12 08a211a5-3809-49d9-8a04-48e6b813af1c Article (Published version) Restricted Negro F Int J Obes (Lond) 2012, 36(12) 1503.pdf 2483477 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity	International journal of obesity			2012	769	5

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Supale, Radhika