NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

Jaquet, Vincent; Marcoux, Julien; Forest, Eric; Leidal, Kevin; McCormick, Sally; Westermaier, Yvonne; Perozzo, Remo; Plastre, Olivier; Fioraso Cartier, Laetitia; Diebold, Becky; Scapozza, Leonardo; Nauseef, William; Fieschi, Franck; Krause, Karl-Heinz; Bedard, Karen

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Title		NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action
Authors		Jaquet, Vincent Marcoux, Julien Forest, Eric Leidal, Kevin McCormick, Sally Westermaier, Yvonne Perozzo, Remo Plastre, Olivier Fioraso Cartier, Laetitia Diebold, Becky Scapozza, Leonardo Nauseef, William Fieschi, Franck Krause, Karl-Heinz Bedard, Karen show all authors [1 - 15]
Published in		British Journal of Pharmacology. 2011, vol. 164, no. 2b, p. 507-20
Abstract		Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and shows benefits in models of neurodegenerative disease, cancer and arthritis, although its mechanism of action is incompletely understood.
Keywords		Animals — CHO Cells — Cell Line — Cell Line, Transformed — Cricetinae — Cytosol/drug effects/metabolism — HEK293 Cells — Humans — Hydrogen Peroxide/metabolism — NADPH Oxidase/antagonists & inhibitors/metabolism — Neutrophils/drug effects/metabolism — Onium Compounds/pharmacology — Oxidoreductases/metabolism — Oxygen/metabolism — Protein Binding/drug effects — Protein Isoforms — Protein Transport/drug effects — Reactive Oxygen Species/antagonists & inhibitors/metabolism — Superoxides/metabolism — Triterpenes/pharmacology — Src Homology Domains/drug effects
Identifiers		DOI: 10.1111/j.1476-5381.2011.01439.x PMID: 21501142
Full text		Article (Published version) (1.4 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté des sciences / Section des sciences pharmaceutiques
Research groups		HIV (835) Radicaux libres et cellules souches embryonnaires (60) Groupe Schaller Karl-Lothard (neurochirurgie) (851)
Citation (ISO format)		JAQUET, Vincent et al. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. In: British Journal of Pharmacology, 2011, vol. 164, n° 2b, p. 507-20. https://archive-ouverte.unige.ch/unige:25563