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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

Marcoux, Julien
Forest, Eric
Leidal, Kevin
McCormick, Sally
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Published in British Journal of Pharmacology. 2011, vol. 164, no. 2b, p. 507-20
Abstract Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and shows benefits in models of neurodegenerative disease, cancer and arthritis, although its mechanism of action is incompletely understood.
Keywords AnimalsCHO CellsCell LineCell Line, TransformedCricetinaeCytosol/drug effects/metabolismHEK293 CellsHumansHydrogen Peroxide/metabolismNADPH Oxidase/antagonists & inhibitors/metabolismNeutrophils/drug effects/metabolismOnium Compounds/pharmacologyOxidoreductases/metabolismOxygen/metabolismProtein Binding/drug effectsProtein IsoformsProtein Transport/drug effectsReactive Oxygen Species/antagonists & inhibitors/metabolismSuperoxides/metabolismTriterpenes/pharmacologySrc Homology Domains/drug effects
PMID: 21501142
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Research groups Groupe Schaller Karl-Lothard (neurochirurgie) (851)
HIV (835)
Radicaux libres et cellules souches embryonnaires (60)
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JAQUET, Vincent et al. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. In: British Journal of Pharmacology, 2011, vol. 164, n° 2b, p. 507-20. doi: 10.1111/j.1476-5381.2011.01439.x https://archive-ouverte.unige.ch/unige:25563

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Deposited on : 2013-01-16

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