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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action |
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Published in | British Journal of Pharmacology. 2011, vol. 164, no. 2b, p. 507-20 | |
Abstract | Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and shows benefits in models of neurodegenerative disease, cancer and arthritis, although its mechanism of action is incompletely understood. | |
Keywords | Animals — CHO Cells — Cell Line — Cell Line, Transformed — Cricetinae — Cytosol/drug effects/metabolism — HEK293 Cells — Humans — Hydrogen Peroxide/metabolism — NADPH Oxidase/antagonists & inhibitors/metabolism — Neutrophils/drug effects/metabolism — Onium Compounds/pharmacology — Oxidoreductases/metabolism — Oxygen/metabolism — Protein Binding/drug effects — Protein Isoforms — Protein Transport/drug effects — Reactive Oxygen Species/antagonists & inhibitors/metabolism — Superoxides/metabolism — Triterpenes/pharmacology — Src Homology Domains/drug effects | |
Identifiers | PMID: 21501142 | |
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Research groups | Groupe Schaller Karl-Lothard (neurochirurgie) (851) HIV (835) Radicaux libres et cellules souches embryonnaires (60) | |
Citation (ISO format) | JAQUET, Vincent et al. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. In: British Journal of Pharmacology, 2011, vol. 164, n° 2b, p. 507-20. doi: 10.1111/j.1476-5381.2011.01439.x https://archive-ouverte.unige.ch/unige:25563 |