NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

Jaquet, Vincent; Marcoux, Julien; Forest, Eric; Leidal, Kevin; McCormick, Sally; Westermaier, Yvonne; Perozzo, Remo; Plastre, Olivier; Fioraso Cartier, Laetitia; Diebold, Becky; Scapozza, Leonardo; Nauseef, William; Fieschi, Franck; Krause, Karl-Heinz; Bedard, Karen

doi:10.1111/j.1476-5381.2011.01439.x

Scientific article

English

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

ContributorsJaquet, Vincent; Marcoux, Julien; Forest, Eric; Leidal, Kevin; McCormick, Sally; Westermaier, Yvonne; Perozzo, Remo; Plastre, Olivier; Fioraso Cartier, Laetitia; Diebold, Becky; Scapozza, Leonardo; Nauseef, William; Fieschi, Franck; Krause, Karl-Heinz; Bedard, Karen

Published inBritish journal of pharmacology, vol. 164, no. 2b, p. 507-520

Publication date2011

Abstract

Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and shows benefits in models of neurodegenerative disease, cancer and arthritis, although its mechanism of action is incompletely understood.

Keywords

Animals
CHO Cells
Cell Line
Cell Line, Transformed
Cricetinae
Cytosol/drug effects/metabolism
HEK293 Cells
Humans
Hydrogen Peroxide/metabolism
NADPH Oxidase/antagonists & inhibitors/metabolism
Neutrophils/drug effects/metabolism
Onium Compounds/pharmacology
Oxidoreductases/metabolism
Oxygen/metabolism
Protein Binding/drug effects
Protein Isoforms
Protein Transport/drug effects
Reactive Oxygen Species/antagonists & inhibitors/metabolism
Superoxides/metabolism
Triterpenes/pharmacology
Src Homology Domains/drug effects

Affiliation entities

Research groups

Citation (ISO format)

JAQUET, Vincent et al. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. In: British journal of pharmacology, 2011, vol. 164, n° 2b, p. 507–520. doi: 10.1111/j.1476-5381.2011.01439.x

Article (Published version)

Identifiers

PID : unige:25563
DOI : 10.1111/j.1476-5381.2011.01439.x
PMID : 21501142

Journal ISSN0007-1188

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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

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