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Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation

ContributorsLou, Qiang; Zhu, Tao; Hu, Jian; Ben, Haijing; Yang, Jinsong; Yu, Fangyou; Liu, Jingran; Wu, Yang; Fischer, Adrien; Francois, Patriceorcid; Schrenzel, Jacques; Qu, Di
Published inBMC Microbiology, vol. 11, 146
Publication date2011
Abstract

Staphylococcus epidermidis (SE) has emerged as one of the most important causes of nosocomial infections. The SaeRS two-component signal transduction system (TCS) influences virulence and biofilm formation in Staphylococcus aureus. The deletion of saeR in S. epidermidis results in impaired anaerobic growth and decreased nitrate utilization. However, the regulatory function of SaeRS on biofilm formation and autolysis in S. epidermidis remains unclear.

Keywords
  • Bacterial Proteins/genetics/metabolism
  • Bacteriolysis
  • Biofilms/growth & development
  • DNA, Bacterial/metabolism
  • Gene Deletion
  • Gene Expression Regulation, Bacterial
  • Genetic Complementation Test
  • Microbial Viability
  • Signal Transduction
  • Staphylococcus epidermidis/genetics/growth & development/physiology
  • Transcription Factors/genetics/metabolism
Affiliation entities
Research groups
Citation (ISO format)
LOU, Qiang et al. Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation. In: BMC Microbiology, 2011, vol. 11, p. 146. doi: 10.1186/1471-2180-11-146
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN1471-2180
641views
361downloads

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