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Title

Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation

Authors
Lou, Qiang
Zhu, Tao
Hu, Jian
Ben, Haijing
Yang, Jinsong
Yu, Fangyou
Liu, Jingran
Wu, Yang
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Published in BMC Microbiology. 2011, vol. 11, p. 146
Abstract Staphylococcus epidermidis (SE) has emerged as one of the most important causes of nosocomial infections. The SaeRS two-component signal transduction system (TCS) influences virulence and biofilm formation in Staphylococcus aureus. The deletion of saeR in S. epidermidis results in impaired anaerobic growth and decreased nitrate utilization. However, the regulatory function of SaeRS on biofilm formation and autolysis in S. epidermidis remains unclear.
Keywords Bacterial Proteins/genetics/metabolismBacteriolysisBiofilms/growth & developmentDNA, Bacterial/metabolismGene DeletionGene Expression Regulation, BacterialGenetic Complementation TestMicrobial ViabilitySignal TransductionStaphylococcus epidermidis/genetics/growth & development/physiologyTranscription Factors/genetics/metabolism
Identifiers
PMID: 21702925
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Article (Published version) (3.2 MB) - public document Free access
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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LOU, Qiang et al. Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation. In: BMC Microbiology, 2011, vol. 11, p. 146. https://archive-ouverte.unige.ch/unige:25412

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Deposited on : 2013-01-11

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