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Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass |
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Published in | Cell metabolism. 2011, vol. 14, no. 3, p. 365-77 | |
Abstract | Decreased β cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented β cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of β cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic β cell mass. | |
Keywords | Adolescent — Amino Acid Sequence — Amyloid Precursor Protein Secretases/antagonists & inhibitors/genetics/metabolism — Animals — Aspartic Acid Endopeptidases/antagonists & inhibitors/genetics/metabolism — Blood Glucose/analysis — Cells, Cultured — Diabetes Mellitus, Type 2/drug therapy/genetics/metabolism — Enzyme Inhibitors/pharmacology — Female — Gene Silencing/drug effects — Humans — Insulin/metabolism/pharmacology — Insulin Resistance — Insulin-Secreting Cells/cytology/drug effects/metabolism — Membrane Glycoproteins/antagonists & inhibitors/genetics/metabolism — Mice — Mice, Inbred C57BL — Middle Aged — Molecular Sequence Data — Plasmids — RNA, Small Interfering/pharmacology — Reverse Transcriptase Polymerase Chain Reaction — Signal Transduction/genetics — Species Specificity — Substrate Specificity — Transfection | |
Identifiers | PMID: 21907142 | |
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Research groups | Cultures cellulaires et transplantations (519) La transplantation d'îlots de Langerhans (623) | |
Citation (ISO format) | ESTERHÁZY, Daria et al. Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. In: Cell metabolism, 2011, vol. 14, n° 3, p. 365-77. doi: 10.1016/j.cmet.2011.06.018 https://archive-ouverte.unige.ch/unige:25023 |