UNIGE document Scientific Article
previous document  unige:25023  next document
add to browser collection
Title

Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass

Authors
Esterházy, Daria
Stützer, Ina
Rechsteiner, Markus P
Beauchamp, Jeremy
Döbeli, Heinz
Hilpert, Hans
Matile, Hugues
show hidden authors show all authors [1 - 20]
Published in Cell Metabolism. 2011, vol. 14, no. 3, p. 365-77
Abstract Decreased β cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented β cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of β cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic β cell mass.
Keywords AdolescentAmino Acid SequenceAmyloid Precursor Protein Secretases/antagonists & inhibitors/genetics/metabolismAnimalsAspartic Acid Endopeptidases/antagonists & inhibitors/genetics/metabolismBlood Glucose/analysisCells, CulturedDiabetes Mellitus, Type 2/drug therapy/genetics/metabolismEnzyme Inhibitors/pharmacologyFemaleGene Silencing/drug effectsHumansInsulin/metabolism/pharmacologyInsulin ResistanceInsulin-Secreting Cells/cytology/drug effects/metabolismMembrane Glycoproteins/antagonists & inhibitors/genetics/metabolismMiceMice, Inbred C57BLMiddle AgedMolecular Sequence DataPlasmidsRNA, Small Interfering/pharmacologyReverse Transcriptase Polymerase Chain ReactionSignal Transduction/geneticsSpecies SpecificitySubstrate SpecificityTransfection
Identifiers
PMID: 21907142
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Cultures cellulaires et transplantations (519)
La transplantation d'îlots de Langerhans (623)
Citation
(ISO format)
ESTERHÁZY, Daria et al. Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. In: Cell Metabolism, 2011, vol. 14, n° 3, p. 365-77. https://archive-ouverte.unige.ch/unige:25023

350 hits

0 download

Update

Deposited on : 2013-01-07

Export document
Format :
Citation style :