Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass
ContributorsEsterházy, Daria; Stützer, Ina; Wang, Haiyan; Rechsteiner, Markus P; Beauchamp, Jeremy; Döbeli, Heinz; Hilpert, Hans; Matile, Hugues; Prummer, Michael; Schmidt, Alexander; Lieske, Nora; Boehm, Bernhard; Marselli, Lorella; Bosco, Domenico; Kerr-Conte, Julie; Aebersold, Ruedi; Spinas, Giatgen Andreia; Moch, Holger; Migliorini, Cristiano; Stoffel, Markus
Published inCell metabolism, vol. 14, no. 3, p. 365-377
Publication date2011
Abstract
Keywords
- Adolescent
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases/antagonists & inhibitors/genetics/metabolism
- Animals
- Aspartic Acid Endopeptidases/antagonists & inhibitors/genetics/metabolism
- Blood Glucose/analysis
- Cells, Cultured
- Diabetes Mellitus, Type 2/drug therapy/genetics/metabolism
- Enzyme Inhibitors/pharmacology
- Female
- Gene Silencing/drug effects
- Humans
- Insulin/metabolism/pharmacology
- Insulin Resistance
- Insulin-Secreting Cells/cytology/drug effects/metabolism
- Membrane Glycoproteins/antagonists & inhibitors/genetics/metabolism
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Molecular Sequence Data
- Plasmids
- RNA, Small Interfering/pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction/genetics
- Species Specificity
- Substrate Specificity
- Transfection
Affiliation
Citation (ISO format)
ESTERHÁZY, Daria et al. Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass. In: Cell metabolism, 2011, vol. 14, n° 3, p. 365–377. doi: 10.1016/j.cmet.2011.06.018
Main files (1)
Article (Published version)

Identifiers
- PID : unige:25023
- DOI : 10.1016/j.cmet.2011.06.018
- PMID : 21907142
ISSN of the journal1550-4131