Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study

Lee, Andie S.; Macedo Vinas, Marina; Francois, Patrice; Renzi, Gesuele; Schrenzel, Jacques; Vernaz-Hegi, Nathalie; Pittet, Didier; Harbarth, Stéphan Juergen

doi:10.1093/cid/cir233

Scientific article

English

Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study

ContributorsLee, Andie S.; Macedo Vinas, Marina; Francois, Patrice

; Renzi, Gesuele; Schrenzel, Jacques; Vernaz-Hegi, Nathalie; Pittet, Didier; Harbarth, Stéphan Juergen

Published inClinical infectious diseases, vol. 52, no. 12, p. 1422-1430

Publication date2011

Abstract

The clinical importance of low-level mupirocin resistance and genotypic chlorhexidine resistance remains unclear. We aimed to determine whether resistance to these agents increases the risk of persistent methicillin-resistant Staphylococcus aureus (MRSA) carriage after their use for topical decolonization therapy.

Keywords

Administration, Topical
Aged
Aged, 80 and over
Anti-Infective Agents, Local/administration & dosage/pharmacology
Carrier State/drug therapy/microbiology
Case-Control Studies
Chlorhexidine/administration & dosage/pharmacology
DNA, Bacterial/genetics
Drug Resistance, Bacterial
Female
Genes, Bacterial
Genotype
Humans
Male
Methicillin-Resistant Staphylococcus aureus/drug effects/isolation & purification
Middle Aged
Mupirocin/administration & dosage/pharmacology
Polymerase Chain Reaction/methods
Staphylococcal Infections/drug therapy/microbiology
Treatment Outcome

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Citation (ISO format)

LEE, Andie S. et al. Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study. In: Clinical infectious diseases, 2011, vol. 52, n° 12, p. 1422–1430. doi: 10.1093/cid/cir233

Article (Published version)

Identifiers

PID : unige:25014
DOI : 10.1093/cid/cir233
PMID : 21628482

ISSN of the journal1058-4838

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Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study

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