Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients

Geneva University Hospitals H1N1 study group

doi:10.3324/haematol.2011.040386

Scientific article

English

Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients

ContributorsGeneva University Hospitals H1N1 study group

CollaboratorsMohty, Bilal; Bel, Michael; Vukicevic Verhille, Marija; Nagy, Monika; Levrat, Emmanuel; Meier, Sara; Grillet, Stéphane; Combescure, Christophe

; Kaiser, Laurent; Chalandon, Yves

; Passweg, Jakob; Siegrist, Claire-Anne; Roosnek, Eddy Emile; Posfay Barbe, Klara; Sealy, Gregg; Charvat-Jackson, Sandrine; Desmeules, Jules Alexandre; Verdon, Mélanie; Hirschel, Bernard; Calmy, Alexandra

; Nguyen, Alexandra; Delhumeau-Cartier, Cécile; Ambrosini, Joëlle; Gabay, Cem; Guerne, Pierre-André; Seebach, Jorg Dieter; Ribi, Camillo; Villard, Jean; Dietrich, Pierre-Yves; George, Anne-Claude Catherine; Favet, Laurence; Van Delden, Christian; Morard, Isabelle; Mentha, Gilles; Giostra, Emiliano; Hadaya, Karine; Martin, Pierre-Yves; Gasche-Soccal, Paola Marina Alessandra; Berney, Thierry; Noble, Stéphane Laurent

; Yerly Ferrillo, Sabine; Thomas, Yves; Wunderli, Werner

Published inHaematologica, vol. 96, no. 6, p. 896-904

Publication date2011

Abstract

Responses to influenza vaccines are poorly characterized in immunocompromised patients. The goal of this study was to assess the efficacy of the AS03-adjuvanted influenza H1N1/A/09 vaccine in allogeneic hematopoietic stem cell transplant recipients.

Keywords

Adult
Aged
Antibodies, Viral/blood/immunology
Antibody Formation/immunology
Female
Graft vs Host Disease/immunology
Hematopoietic Stem Cell Transplantation/adverse effects
Humans
Immunity, Humoral/immunology
Immunization
Immunocompromised Host
Influenza Vaccines/adverse effects/immunology
Male
Middle Aged
Transplantation, Homologous/immunology
Young Adult

Affiliation entities

Research groups

Citation (ISO format)

Geneva University Hospitals H1N1 study group. Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients. In: Haematologica, 2011, vol. 96, n° 6, p. 896–904. doi: 10.3324/haematol.2011.040386

Article (Published version)

Identifiers

PID : unige:24949
DOI : 10.3324/haematol.2011.040386
PMID : 21422117

Journal ISSN0390-6078

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Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients

Responses to influenza vaccines are poorly characterized in immunocompromised patients. The goal of this study was to assess the efficacy of the AS03-adjuvanted influenza H1N1/A/09 vaccine in allogeneic hematopoietic stem cell transplant recipients.

Technical informations