en
Scientific article
Open access
English

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

Published inDiabetes, vol. 60, no. 11, p. 2872-2882
Publication date2011
Abstract

To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.

Keywords
  • Animals
  • Apoptosis/drug effects
  • Cell Count
  • Diabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathology
  • Diphtheria Toxin/toxicity
  • Glucagon/blood/genetics/metabolism
  • Glucagon-Secreting Cells/drug effects/metabolism/pathology/secretion
  • Hyperglycemia/chemically induced/prevention & control
  • Hypoglycemia/prevention & control
  • Insulin/blood/metabolism
  • Insulin-Secreting Cells/drug effects/metabolism/pathology/secretion
  • Intercellular Signaling Peptides and Proteins/genetics/metabolism
  • Male
  • Mice
  • Mice, Transgenic
  • Pancreas/drug effects/metabolism/pathology
  • Promoter Regions, Genetic
  • Receptors, Glucagon/metabolism
  • Selective Estrogen Receptor Modulators/pharmacology
  • Signal Transduction
  • Streptozocin/toxicity
  • Tamoxifen/pharmacology
Citation (ISO format)
THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872–2882. doi: 10.2337/db11-0876
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0012-1797
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325downloads

Technical informations

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First validation10/25/2012 7:56:00 AM
Update time03/14/2023 5:48:26 PM
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