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Title

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
Authors
Thorel, Fabrizio
Damond, Nicolas
Chera, Simona
Wiederkehr, Andreas
Thorens, Bernard
Meda, Paolo
Wollheim, Claes B
Herrera, Pedro Luis
Published in Diabetes. 2011, vol. 60, no. 11, p. 2872-82
Abstract To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.
Keywords Animals — Apoptosis/drug effects — Cell Count — Diabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathology — Diphtheria Toxin/toxicity — Glucagon/blood/genetics/metabolism — Glucagon-Secreting Cells/drug effects/metabolism/pathology/secretion — Hyperglycemia/chemically induced/prevention & control — Hypoglycemia/prevention & control — Insulin/blood/metabolism — Insulin-Secreting Cells/drug effects/metabolism/pathology/secretion — Intercellular Signaling Peptides and Proteins/genetics/metabolism — Male — Mice — Mice, Transgenic — Pancreas/drug effects/metabolism/pathology — Promoter Regions, Genetic — Receptors, Glucagon/metabolism — Selective Estrogen Receptor Modulators/pharmacology — Signal Transduction — Streptozocin/toxicity — Tamoxifen/pharmacology
Identifiers
PMID: 21926270
Full text
Article (Published version) (2.1 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups Couplage cellulaire et connexines (136)
Types cellulaires pancréatiques pendant l'ontogénèse (522)
Citation
(ISO format) 		THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872-82. https://archive-ouverte.unige.ch/unige:24821

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Deposited on : 2012-12-20

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