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Title

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

Authors
Wollheim, Claes B
Published in Diabetes. 2011, vol. 60, no. 11, p. 2872-82
Abstract To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.
Keywords AnimalsApoptosis/drug effectsCell CountDiabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathologyDiphtheria Toxin/toxicityGlucagon/blood/genetics/metabolismGlucagon-Secreting Cells/drug effects/metabolism/pathology/secretionHyperglycemia/chemically induced/prevention & controlHypoglycemia/prevention & controlInsulin/blood/metabolismInsulin-Secreting Cells/drug effects/metabolism/pathology/secretionIntercellular Signaling Peptides and Proteins/genetics/metabolismMaleMiceMice, TransgenicPancreas/drug effects/metabolism/pathologyPromoter Regions, GeneticReceptors, Glucagon/metabolismSelective Estrogen Receptor Modulators/pharmacologySignal TransductionStreptozocin/toxicityTamoxifen/pharmacology
Identifiers
PMID: 21926270
Full text
Article (Published version) (2.1 MB) - public document Free access
Structures
Research groups Couplage cellulaire et connexines (136)
Types cellulaires pancréatiques pendant l'ontogénèse (522)
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(ISO format)
THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872-82. https://archive-ouverte.unige.ch/unige:24821

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Deposited on : 2012-12-20

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