Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

Thorel, Fabrizio; Damond, Nicolas; Chera, Simona; Wiederkehr, Andreas; Thorens, Bernard; Meda, Paolo; Wollheim, Claes; Herrera, Pedro Luis

doi:10.2337/db11-0876

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Title		Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
Authors		Thorel, Fabrizio Damond, Nicolas Chera, Simona Wiederkehr, Andreas Thorens, Bernard Meda, Paolo Wollheim, Claes Herrera, Pedro Luis
Published in		Diabetes. 2011, vol. 60, no. 11, p. 2872-82
Abstract		To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.
Keywords		Animals — Apoptosis/drug effects — Cell Count — Diabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathology — Diphtheria Toxin/toxicity — Glucagon/blood/genetics/metabolism — Glucagon-Secreting Cells/drug effects/metabolism/pathology/secretion — Hyperglycemia/chemically induced/prevention & control — Hypoglycemia/prevention & control — Insulin/blood/metabolism — Insulin-Secreting Cells/drug effects/metabolism/pathology/secretion — Intercellular Signaling Peptides and Proteins/genetics/metabolism — Male — Mice — Mice, Transgenic — Pancreas/drug effects/metabolism/pathology — Promoter Regions, Genetic — Receptors, Glucagon/metabolism — Selective Estrogen Receptor Modulators/pharmacology — Signal Transduction — Streptozocin/toxicity — Tamoxifen/pharmacology
Identifiers		DOI: 10.2337/db11-0876 PMID: 21926270
Full text		Article (Published version) (2.1 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Couplage cellulaire et connexines (136) Types cellulaires pancréatiques pendant l'ontogénèse (522)
Citation (ISO format)		THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872-82. doi: 10.2337/db11-0876 https://archive-ouverte.unige.ch/unige:24821