Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

Thorel, Fabrizio; Damond, Nicolas; Chera, Simona; Wiederkehr, Andreas; Thorens, Bernard; Meda, Paolo; Wollheim, Claes B; Herrera, Pedro Luis

doi:10.2337/db11-0876

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Title		Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
Authors		Thorel, Fabrizio Damond, Nicolas Chera, Simona Wiederkehr, Andreas Thorens, Bernard Meda, Paolo Wollheim, Claes B Herrera, Pedro Luis
Published in		Diabetes. 2011, vol. 60, no. 11, p. 2872-82
Abstract		To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.
Keywords		Animals — Apoptosis/drug effects — Cell Count — Diabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathology — Diphtheria Toxin/toxicity — Glucagon/blood/genetics/metabolism — Glucagon-Secreting Cells/drug effects/metabolism/pathology/secretion — Hyperglycemia/chemically induced/prevention & control — Hypoglycemia/prevention & control — Insulin/blood/metabolism — Insulin-Secreting Cells/drug effects/metabolism/pathology/secretion — Intercellular Signaling Peptides and Proteins/genetics/metabolism — Male — Mice — Mice, Transgenic — Pancreas/drug effects/metabolism/pathology — Promoter Regions, Genetic — Receptors, Glucagon/metabolism — Selective Estrogen Receptor Modulators/pharmacology — Signal Transduction — Streptozocin/toxicity — Tamoxifen/pharmacology
Identifiers		DOI: 10.2337/db11-0876 PMID: 21926270
Full text		Article (Published version) (2.1 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Couplage cellulaire et connexines (136) Types cellulaires pancréatiques pendant l'ontogénèse (522)
Citation (ISO format)		THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872-82. doi: 10.2337/db11-0876 https://archive-ouverte.unige.ch/unige:24821