Title |
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Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
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Published in |
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Diabetes. 2011, vol. 60, no. 11, p. 2872-82 |
Abstract |
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To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis. |
Keywords |
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Animals — Apoptosis/drug effects — Cell Count — Diabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathology — Diphtheria Toxin/toxicity — Glucagon/blood/genetics/metabolism — Glucagon-Secreting Cells/drug effects/metabolism/pathology/secretion — Hyperglycemia/chemically induced/prevention & control — Hypoglycemia/prevention & control — Insulin/blood/metabolism — Insulin-Secreting Cells/drug effects/metabolism/pathology/secretion — Intercellular Signaling Peptides and Proteins/genetics/metabolism — Male — Mice — Mice, Transgenic — Pancreas/drug effects/metabolism/pathology — Promoter Regions, Genetic — Receptors, Glucagon/metabolism — Selective Estrogen Receptor Modulators/pharmacology — Signal Transduction — Streptozocin/toxicity — Tamoxifen/pharmacology |
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Full text |
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Structures |
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Research groups | | Couplage cellulaire et connexines (136) Types cellulaires pancréatiques pendant l'ontogénèse (522) |
Citation (ISO format) | | THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872-82. doi: 10.2337/db11-0876 https://archive-ouverte.unige.ch/unige:24821 |