Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

Thorel, Fabrizio; Damond, Nicolas; Chera, Simona; Wiederkehr, Andreas; Thorens, Bernard; Meda, Paolo; Wollheim, Claes; Herrera, Pedro Luis

doi:10.2337/db11-0876

Scientific article

English

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

ContributorsThorel, Fabrizio; Damond, Nicolas; Chera, Simona; Wiederkehr, Andreas; Thorens, Bernard; Meda, Paolo; Wollheim, Claes; Herrera, Pedro Luis

Published inDiabetes, vol. 60, no. 11, p. 2872-2882

Publication date2011

Abstract

To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.

Keywords

Animals
Apoptosis/drug effects
Cell Count
Diabetes Mellitus, Experimental/blood/chemically induced/metabolism/pathology
Diphtheria Toxin/toxicity
Glucagon/blood/genetics/metabolism
Glucagon-Secreting Cells/drug effects/metabolism/pathology/secretion
Hyperglycemia/chemically induced/prevention & control
Hypoglycemia/prevention & control
Insulin/blood/metabolism
Insulin-Secreting Cells/drug effects/metabolism/pathology/secretion
Intercellular Signaling Peptides and Proteins/genetics/metabolism
Male
Mice
Mice, Transgenic
Pancreas/drug effects/metabolism/pathology
Promoter Regions, Genetic
Receptors, Glucagon/metabolism
Selective Estrogen Receptor Modulators/pharmacology
Signal Transduction
Streptozocin/toxicity
Tamoxifen/pharmacology

Affiliation entities

Research groups

Citation (ISO format)

THOREL, Fabrizio et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. In: Diabetes, 2011, vol. 60, n° 11, p. 2872–2882. doi: 10.2337/db11-0876

Article (Published version)

Identifiers

PID : unige:24821
DOI : 10.2337/db11-0876
PMID : 21926270

Journal ISSN0012-1797

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Creation25/10/2012 07:56:00

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Update14/03/2023 17:48:26

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Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis.

Technical informations