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Polyarthrite rhumatoïde,méthotrexate et fibrose pulmonaire : quelles évidences ?

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Published in Revue médicale suisse. 2010, vol. 6, no. 240, p. 547-554
Abstract Pulmonary fibrosis is an extraarticular manifestation of rheumatoid arthritis (RA), which appears between 20 to 40% of cases. MTX is an ordinary treatment used for patients with RA. It has been suggested in some studies that a link between the use of MTX and the appearance of pulmonary fibrosis exists. Furthermore, the chronic use of MTX has been associated with the development of hepatic cirrhosis. Adenosine, a key molecule in the anti-inflammatory action of MTX seems to have a pro-fibrotic effect in some experimental models, thereby suggesting a mechanism through which MTX could lead to a fibrotic process. However, in spite of these experimental models, clinical studies have not permitted to confirm the pathogenic role of MTX in pulmonary fibrosis.
Keywords Adenosine/adverse effects/metabolismAnimalsArthritis, Rheumatoid/complications/drug therapy/pathologyHumansLiver Cirrhosis/chemically inducedMethotrexate/adverse effects/therapeutic usePulmonary Fibrosis/chemically induced/etiologySmoking/adverse effects
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PMID: 20408459
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Research groups Mécanisme de l'inflammation articulaire (44)
Acquisition de l'expertise médicale (662)
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SCHALLER, Dorian, NENDAZ, Mathieu, GABAY, Cem. Polyarthrite rhumatoïde,méthotrexate et fibrose pulmonaire : quelles évidences ?. In: Revue médicale suisse, 2010, vol. 6, n° 240, p. 547-554. https://archive-ouverte.unige.ch/unige:24251

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Deposited on : 2012-11-30

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