Polyarthrite rhumatoïde,méthotrexate et fibrose pulmonaire : quelles évidences ?

Article Article scientifique Article Polyarthrite rhumatoïde,méthotrexate et fibrose pulmonaire : quelles évidences ? fre 2010 author Schaller Dorian 502925 author Nendaz Mathieu 0000-0003-3795-3254 33708 author Gabay Cem 70978 547-554 20408459 1660-9379 Pulmonary fibrosis is an extraarticular manifestation of rheumatoid arthritis (RA), which appears between 20 to 40% of cases. MTX is an ordinary treatment used for patients with RA. It has been suggested in some studies that a link between the use of MTX and the appearance of pulmonary fibrosis exists. Furthermore, the chronic use of MTX has been associated with the development of hepatic cirrhosis. Adenosine, a key molecule in the anti-inflammatory action of MTX seems to have a pro-fibrotic effect in some experimental models, thereby suggesting a mechanism through which MTX could lead to a fibrotic process. However, in spite of these experimental models, clinical studies have not permitted to confirm the pathogenic role of MTX in pulmonary fibrosis. Adenosine/adverse effects/metabolism Animals Arthritis, Rheumatoid/complications/drug therapy/pathology Humans Liver Cirrhosis/chemically induced Methotrexate/adverse effects/therapeutic use Pulmonary Fibrosis/chemically induced/etiology Smoking/adverse effects Dewey 610/370 Dewey 616 48 Unité de développement et de recherche en éducation médicale 204 56 Département de médecine 221 false 395 Acquisition de l'expertise médicale 662 28 Inflammation articulaire 44 Revue médicale suisse 6 240 e626432d-1bdf-4f36-a8af-2ee082f06c77 Article (Published version) Restricted 2010_schaller_mtx et fibrose pulm_RMS.pdf 700119 application/pdf restrictedAccess Faculté de médecine / Unité de développement et de recherche en éducation médicale Faculté de médecine / Section de médecine clinique / Département de médecine

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Polyarthrite rhumatoïde,méthotrexate et fibrose pulmonaire : quelles évidences ?	Revue médicale suisse			2010	853	1

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Schaller, Dorian