en
Doctoral thesis
Open access
English

Interfacing sequences and structures of proteins: applications to protein annotation and sequence feature visualization

Defense date2009-10-16
Abstract

UniProtKB (UniProt Knowledgebase) annotation and 3D-structures in PDB (Protein Data Bank) bring important and complementary information related to protein features and function. On one hand, part of the annotation of protein features present in UniProtKB is imported from 3D structural data. On the other hand, the transfer of sequential protein features to structures provides often an additional level of understanding about protein function. Both of these tasks require an interface between sequences and structures. The main subject of this thesis is to create an integrated platform to allow easy interplay between protein sequences and structures in order to simplify and help scientists in the two tasks previously cited. The foundation of such system is a unique, bidirectional and up-to-date mapping between sequences and structures.

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Keywords
  • 3D structure
  • Protein sequence
  • Mapping
  • UniProtKB
  • UniProtKB/Swiss-Prot
  • PDB
  • Database
  • Curation
  • Mapping
  • SSMap
  • SAALSA
  • Protéine
  • Base de données
  • Annotation
Citation (ISO format)
DAVID, Fabrice Pierre André. Interfacing sequences and structures of proteins: applications to protein annotation and sequence feature visualization. 2009. doi: 10.13097/archive-ouverte/unige:23831
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Thesis
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Technical informations

Creation07/11/2012 08:52:00
First validation07/11/2012 08:52:00
Update time30/03/2023 10:14:18
Status update30/03/2023 10:14:17
Last indexation29/01/2024 19:35:51
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