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Scientific article
Open access
English

Dicer is required for haploid male germ cell differentiation in mice

Published inPloS one, vol. 6, no. 9, e24821
Publication date2011
Abstract

The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The best-characterized function of miRNAs is gene repression at the post-transcriptional level through the pairing with mRNAs of protein-encoding genes. Small RNAs can also act at the transcriptional level by controlling the epigenetic status of chromatin. Dicer and other mediators of small RNA pathways are present in mouse male germ cells, and several miRNAs and endogenous siRNAs are expressed in the testis, suggesting that Dicer-dependent small RNAs are involved in the control of the precisely timed and highly organised process of spermatogenesis.

Keywords
  • Animals
  • Animals, Newborn
  • Cell Differentiation
  • Centromere/genetics
  • DEAD-box RNA Helicases/deficiency/metabolism
  • DNA Transposable Elements/genetics
  • Gene Deletion
  • Haploidy
  • Infertility, Male/enzymology/pathology
  • Male
  • Meiosis
  • Mice
  • Mice, Knockout
  • Organ Specificity
  • Repetitive Sequences, Nucleic Acid/genetics
  • Ribonuclease III/deficiency/metabolism
  • Spermatids/metabolism/pathology/ultrastructure
  • Spermatocytes/metabolism/pathology/ultrastructure
  • Spermatogenesis
  • Spermatozoa/enzymology/pathology
  • Testis/enzymology/pathology/ultrastructure
Funding
  • Swiss National Science Foundation - FNRS
Citation (ISO format)
KORHONEN, Hanna M et al. Dicer is required for haploid male germ cell differentiation in mice. In: PloS one, 2011, vol. 6, n° 9, p. e24821. doi: 10.1371/journal.pone.0024821
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
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267downloads

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