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Dicer is required for haploid male germ cell differentiation in mice

Korhonen, Hanna M
Meikar, Oliver
Yadav, Ram Prakash
Papaioannou, Marilena D
Da Ros, Matteo
Toppari, Jorma
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Published in PloS one. 2011, vol. 6, no. 9, e24821
Abstract The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The best-characterized function of miRNAs is gene repression at the post-transcriptional level through the pairing with mRNAs of protein-encoding genes. Small RNAs can also act at the transcriptional level by controlling the epigenetic status of chromatin. Dicer and other mediators of small RNA pathways are present in mouse male germ cells, and several miRNAs and endogenous siRNAs are expressed in the testis, suggesting that Dicer-dependent small RNAs are involved in the control of the precisely timed and highly organised process of spermatogenesis.
Keywords AnimalsAnimals, NewbornCell DifferentiationCentromere/geneticsDEAD-box RNA Helicases/deficiency/metabolismDNA Transposable Elements/geneticsGene DeletionHaploidyInfertility, Male/enzymology/pathologyMaleMeiosisMiceMice, KnockoutOrgan SpecificityRepetitive Sequences, Nucleic Acid/geneticsRibonuclease III/deficiency/metabolismSpermatids/metabolism/pathology/ultrastructureSpermatocytes/metabolism/pathology/ultrastructureSpermatogenesisSpermatozoa/enzymology/pathologyTestis/enzymology/pathology/ultrastructure
PMID: 21949761
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Article (Published version) (3.9 MB) - public document Free access
Research groups Mécanismes moléculaires et génétiques du développement sexuel (778)
Types cellulaires pancréatiques pendant l'ontogénèse (522)
Swiss National Science Foundation: FNRS
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KORHONEN, Hanna M et al. Dicer is required for haploid male germ cell differentiation in mice. In: PloS one, 2011, vol. 6, n° 9, p. e24821. doi: 10.1371/journal.pone.0024821 https://archive-ouverte.unige.ch/unige:23483

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Deposited on : 2012-10-18

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