Dicer is required for haploid male germ cell differentiation in mice

Korhonen, Hanna M; Meikar, Oliver; Yadav, Ram Prakash; Papaioannou, Marilena D; Romero, Yannick; Da Ros, Matteo; Herrera, Pedro Luis; Toppari, Jorma; Nef, Serge; Kotaja, Noora

doi:10.1371/journal.pone.0024821

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Title		Dicer is required for haploid male germ cell differentiation in mice
Authors		Korhonen, Hanna M Meikar, Oliver Yadav, Ram Prakash Papaioannou, Marilena D Romero, Yannick Da Ros, Matteo Herrera, Pedro Luis Toppari, Jorma Nef, Serge Kotaja, Noora show all authors [1 - 10]
Published in		PLOS ONE. 2011, vol. 6, no. 9, p. e24821
Abstract		The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The best-characterized function of miRNAs is gene repression at the post-transcriptional level through the pairing with mRNAs of protein-encoding genes. Small RNAs can also act at the transcriptional level by controlling the epigenetic status of chromatin. Dicer and other mediators of small RNA pathways are present in mouse male germ cells, and several miRNAs and endogenous siRNAs are expressed in the testis, suggesting that Dicer-dependent small RNAs are involved in the control of the precisely timed and highly organised process of spermatogenesis.
Keywords		Animals — Animals, Newborn — Cell Differentiation — Centromere/genetics — DEAD-box RNA Helicases/deficiency/metabolism — DNA Transposable Elements/genetics — Gene Deletion — Haploidy — Infertility, Male/enzymology/pathology — Male — Meiosis — Mice — Mice, Knockout — Organ Specificity — Repetitive Sequences, Nucleic Acid/genetics — Ribonuclease III/deficiency/metabolism — Spermatids/metabolism/pathology/ultrastructure — Spermatocytes/metabolism/pathology/ultrastructure — Spermatogenesis — Spermatozoa/enzymology/pathology — Testis/enzymology/pathology/ultrastructure
Identifiers		DOI: 10.1371/journal.pone.0024821 PMID: 21949761
Full text		Article (Published version) (3.9 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research groups		Mécanismes moléculaires et génétiques du développement sexuel (778) Types cellulaires pancréatiques pendant l'ontogénèse (522)
Project		FNS: FNRS
Citation (ISO format)		KORHONEN, Hanna M et al. Dicer is required for haploid male germ cell differentiation in mice. In: PLOS ONE, 2011, vol. 6, n° 9, p. e24821. doi: 10.1371/journal.pone.0024821 https://archive-ouverte.unige.ch/unige:23483