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Title

Dicer is required for haploid male germ cell differentiation in mice

Authors
Korhonen, Hanna M
Meikar, Oliver
Yadav, Ram Prakash
Papaioannou, Marilena D
Da Ros, Matteo
Toppari, Jorma
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Published in PLOS ONE. 2011, vol. 6, no. 9, p. e24821
Abstract The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The best-characterized function of miRNAs is gene repression at the post-transcriptional level through the pairing with mRNAs of protein-encoding genes. Small RNAs can also act at the transcriptional level by controlling the epigenetic status of chromatin. Dicer and other mediators of small RNA pathways are present in mouse male germ cells, and several miRNAs and endogenous siRNAs are expressed in the testis, suggesting that Dicer-dependent small RNAs are involved in the control of the precisely timed and highly organised process of spermatogenesis.
Keywords AnimalsAnimals, NewbornCell DifferentiationCentromere/geneticsDEAD-box RNA Helicases/deficiency/metabolismDNA Transposable Elements/geneticsGene DeletionHaploidyInfertility, Male/enzymology/pathologyMaleMeiosisMiceMice, KnockoutOrgan SpecificityRepetitive Sequences, Nucleic Acid/geneticsRibonuclease III/deficiency/metabolismSpermatids/metabolism/pathology/ultrastructureSpermatocytes/metabolism/pathology/ultrastructureSpermatogenesisSpermatozoa/enzymology/pathologyTestis/enzymology/pathology/ultrastructure
Identifiers
PMID: 21949761
Full text
Article (Published version) (3.9 MB) - public document Free access
Structures
Research groups Mécanismes moléculaires et génétiques du développement sexuel (778)
Types cellulaires pancréatiques pendant l'ontogénèse (522)
Project FNS: FNRS
Citation
(ISO format)
KORHONEN, Hanna M et al. Dicer is required for haploid male germ cell differentiation in mice. In: PLOS ONE, 2011, vol. 6, n° 9, p. e24821. https://archive-ouverte.unige.ch/unige:23483

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Deposited on : 2012-10-18

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