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Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia

Published in Neuroendocrinology Letters. 2010, vol. 31, no. 1, p. 63-6
Abstract Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery. It is a regulator of uterine contractions, of vascular resistance and of volume of the retroplacental blood pool. Recently, it was shown that it could also regulate metalloproteinase 9 activity and thus, invasiveness of trophoblastic cells. Since development of preeclampsia could be initiated by decreased cytotrophoblastic invasion of spiral arterioles and a reduced uteroplacental perfusion, we speculate that circulating P-LAP activity could be decreased during preeclampsia.
Keywords Case-Control StudiesCystinyl Aminopeptidase/blood/metabolismDown-RegulationEnzyme ActivationFemaleGestational AgeHumansPre-Eclampsia/blood/enzymology/metabolismPregnancyPremature Birth/blood/enzymology/metabolismSeverity of Illness IndexTerm Birth/blood/metabolism
PMID: 20150869
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Research groups Groupe Irion Olivier/Boulvain Michel (gynécologie et obstétrique) (272)
Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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LANDAU CAHANA, Ruth et al. Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia. In: Neuroendocrinology Letters, 2010, vol. 31, n° 1, p. 63-6. https://archive-ouverte.unige.ch/unige:21445

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Deposited on : 2012-05-25

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