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Scientific article
English

Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia

Published inNeuro-endocrinology letters, vol. 31, no. 1, p. 63-66
Publication date2010
Abstract

Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery. It is a regulator of uterine contractions, of vascular resistance and of volume of the retroplacental blood pool. Recently, it was shown that it could also regulate metalloproteinase 9 activity and thus, invasiveness of trophoblastic cells. Since development of preeclampsia could be initiated by decreased cytotrophoblastic invasion of spiral arterioles and a reduced uteroplacental perfusion, we speculate that circulating P-LAP activity could be decreased during preeclampsia.

Keywords
  • Case-Control Studies
  • Cystinyl Aminopeptidase/blood/metabolism
  • Down-Regulation
  • Enzyme Activation
  • Female
  • Gestational Age
  • Humans
  • Pre-Eclampsia/blood/enzymology/metabolism
  • Pregnancy
  • Premature Birth/blood/enzymology/metabolism
  • Severity of Illness Index
  • Term Birth/blood/metabolism
Citation (ISO format)
LANDAU CAHANA, Ruth et al. Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia. In: Neuro-endocrinology letters, 2010, vol. 31, n° 1, p. 63–66.
Identifiers
ISSN of the journal0172-780X
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