Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia

Article Article scientifique Article Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia eng 2010 author Landau Cahana Ruth 34689 author Laverriere Alexandra 518947 author Bischof Paul 26504 author Irion Olivier 125635 author Morales Michel Ange 34723 author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 63-66 20150869 0172-780X Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery. It is a regulator of uterine contractions, of vascular resistance and of volume of the retroplacental blood pool. Recently, it was shown that it could also regulate metalloproteinase 9 activity and thus, invasiveness of trophoblastic cells. Since development of preeclampsia could be initiated by decreased cytotrophoblastic invasion of spiral arterioles and a reduced uteroplacental perfusion, we speculate that circulating P-LAP activity could be decreased during preeclampsia. Case-Control Studies Cystinyl Aminopeptidase/blood/metabolism Down-Regulation Enzyme Activation Female Gestational Age Humans Pre-Eclampsia/blood/enzymology/metabolism Pregnancy Premature Birth/blood/enzymology/metabolism Severity of Illness Index Term Birth/blood/metabolism Dewey 576.5 Dewey 618 135 Département de médecine génétique et développement 21D 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 213 Martinez De Tejada Begona 272 Neuro-endocrinology letters 31 1 Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia	Neuro-endocrinology letters			2010	635	0

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Landau Cahana, Ruth