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Protection of C. elegans from anoxia by HYL-2 ceramide synthase

Howell, Kate S
Hengartner, Michael O
Gomez, Marie
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Published in Science. 2009, vol. 324, no. 5925, p. 381-4
Abstract Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival. We describe a pathway involving the HYL-2 ceramide synthase that acts independently of DAF-2. Loss of the ceramide synthase gene hyl-2 results in increased sensitivity of C. elegans to anoxia. C. elegans has two ceramide synthases, hyl-1 and hyl-2, that participate in ceramide biogenesis and affect its ability to survive anoxic conditions. In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL-2 have complementary specificities for fatty acyl chains. These data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia.
Keywords AnimalsApoptosisCaenorhabditis elegans/cytology/genetics/physiologyCaenorhabditis elegans Proteins/genetics/metabolismCell HypoxiaCeramides/biosynthesis/physiologyGene DeletionGenes, HelminthMutationOxidoreductases/genetics/metabolismOxygen/physiologyReceptor, Insulin/genetics/metabolismSaccharomyces cerevisiae/genetics/growth & development/physiologySphingomyelins/biosynthesis/physiologySubstrate SpecificityTransformation, GeneticTransgenes
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MENUZ, Vincent Régis et al. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. In: Science, 2009, vol. 324, n° 5925, p. 381-4. doi: 10.1126/science.1168532 https://archive-ouverte.unige.ch/unige:18788

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Deposited on : 2012-03-13

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