According to legend, an image of the Virgin spoke to Gregory the Great as he prayed in his monastery on the Celio Hill in Rome. On the occasion of the Jubilee of 1600, Cardinal Antonio Maria Salviati commissioned the construction of a chapel to enshrine this Madonna. Carlo Maderno, Annibale Carracci, and Giovanni Battista Ricci, among others, contributed to its realization. The miraculous episode was depicted by placing Gregory within the altarpiece, while the Madonna herself was situated on the lateral wall. This dissertation investigates how the Salviati Chapel participates in the renewed promotion of the cult of the Virgin and of Saint Gregory within the context of the Catholic Reformation. It situates the chapel in relation to contemporary debates on the origins of the Church, the papacy, purgatory, and indulgences. At the same time, it engages with the figure of Gregory as a theorist of images, notably through his well-known conception of images as reading for the illiterate. Considered as a theoretical object, the Salviati Chapel offers a lens through which to interrogate this Gregorian definition by attending to the images themselves and to their broader visual and spatial device. Particular attention is paid to the ways in which the ensemble engages the bodily senses—especially sight and hearing—within a devotional itinerary that includes a sacred well, additional Marian images, and liturgical practice. The point of departure for this research lies in a seemingly minor yet provocative detail: the oblique positioning of the miraculous image of the Madonna. In defiance of the iconic orthodoxy that prescribes a frontal presentation for sacred images, this deviation prompts reflection on how this displacement shapes devotional experience—mediated between the act of seeing and the paradoxical experience of hearing the image’s voice. What emerges is the performative potential of the chapel’s visual program, understood as a means of conforming the believer to the promise of salvation and restoring a face-to-face vision, as announced in Christian eschatology.