Scientific article
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English

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Published inJournal of personalized medicine, vol. 12, no. 9, 1410
Publication date2022-08-30
First online date2022-08-30
Abstract

Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.

Keywords
  • Intracranial aneurysm
  • Subarachnoid hemorrhage
  • Risk factors
  • Location
  • Smoking
  • Hypertension
Funding
  • European Commission - Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage [852173]
Citation (ISO format)
MOREL, Sandrine et al. Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis. In: Journal of personalized medicine, 2022, vol. 12, n° 9, p. 1410. doi: 10.3390/jpm12091410
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Identifiers
ISSN of the journal2075-4426
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Creation09/01/2022 6:07:39 AM
First validation11/23/2023 6:01:52 PM
Update time11/23/2023 6:01:52 PM
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