Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Article Article scientifique Article Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis eng 2022-08-30 2022-08-30 author Morel Sandrine 0000-0003-1538-3553 829024 author Hostettler Isabel 0000-0002-9004-2540 author Spinner Georg author Bourcier Romain author Pera Joanna 0000-0001-6142-2969 author Meling Torstein 0000-0001-6595-0873 914537 Département des neurosciences cliniques (OTONO) author Alg Varinder author Houlden Henry author Bakker Mark 0000-0002-7887-9014 author van’t Hof Femke author Rinkel Gabriel author Foroud Tatiana author Lai Dongbing 0000-0001-7803-580X author Moomaw Charles author Worrall Bradford author Caroff Jildaz author Constant-dits-Beaufils Pacôme author Karakachoff Matilde author Rimbert Antoine author Rouchaud Aymeric author Gaal-Paavola Emilia author Kaukovalta Hanna author Kivisaari Riku author Laakso Aki author Jahromi Behnam 0000-0003-3937-2816 author Tulamo Riikka author Friedrich Christoph 0000-0001-7906-0038 author Dauvillier Jerome author Hirsch Sven 0000-0002-5678-4110 author Isidor Nathalie author Kulcsàr Zolt author Lövblad Karl-Olof 135154 Département de radiologie et informatique médicale (RADIO) author Martin Olivier author Machi Paolo 860889 Département de radiologie et informatique médicale (RADIO) author Mendes Pereira Vitor 696473 author Rüfenacht Daniel author Schaller Karl Lothard 658606 Département des neurosciences cliniques (OTONO) author Schilling Sabine author Slowik Agnieszka author Jaaskelainen Juha author von und zu Fraunberg Mikael author Jiménez-Conde Jordi author Cuadrado-Godia Elisa 0000-0002-9147-875X author Soriano-Tárraga Carolina author Millwood Iona author Walters Robin author Kim Helen author Redon Richard author Ko Nerissa author Rouleau Guy author Lindgren Antti author Niemelä Mika author Desal Hubert 0000-0002-3586-2757 author Woo Daniel author Broderick Joseph author Werring David author Ruigrok Ynte author Bijlenga Philippe Alexandre Pierre 104899 Département des neurosciences cliniques (OTONO) The @neurIST Project The ICAN Study Group Genetics And Observational Subarachnoid Haemorrhage (GOSH) Study Investigators International Stroke Genetics Consortium (ISGC) 1410 10.3390/jpm12091410 36143196 2075-4426 PMC9501769 https://www.mdpi.com/2075-4426/12/9/1410 <p>Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.</p> Intracranial aneurysm Subarachnoid hemorrhage Risk factors Location Smoking Hypertension Dewey 616.8 Dewey 616.0757 Dewey 616.07 European Commission Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage 852173 PRYSM EU H2020 62 Département de radiologie et informatique médicale 227 137 Département de pathologie et immunologie 21F 61 Département des neurosciences cliniques 226 false 470 Ischémie cérébrale et connectivité 801 513 Groupe Schaller Karl Lothard (neurochirurgie) 851 Journal of personalized medicine 12 9 3baabf18-43b9-4197-816e-52642b9bed98 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 2651228 application/pdf CC BY-4.0 2b2e62a6085611f294d00662e977be4e007deaa7f700209892837fc4883e5bab 7c197441-dfc0-495a-9164-78a16d44c476 Supplemental data Public jpm-1722577-SI.pdf 356313 application/pdf 9474b63b2132f40f0b1e5b298c2a6f4881b9265ee88937efff9f86830a22bee9 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis	Journal of personalized medicine	2022	104	79
Erratum to "Adipokines at the crossroad between obesity and cardiovascular disease" (Thromb Haemost 2015; 113: 553-566)	Thrombosis and haemostasis	2015	602	280

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Morel, Sandrine