Scientific article
English

The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events

Published inJournal of acquired immune deficiency syndromes, vol. 71, no. 3, p. 302-309
Publication date2016-03-01
Abstract

Objectives: In HIV-negative populations, light-to-moderate alcohol consumption is associated with a lower cardiovascular morbidity and mortality than alcohol abstention. Whether the same holds true for HIV-infected individuals has not been evaluated in detail.

Design: Cohort study.

Methods: Adults on antiretroviral therapy in the Swiss HIV Cohort Study with follow-up after August 2005 were included. We categorized alcohol consumption into: abstention or very low (<1 g/d), low (1-9 g/d), moderate (10-29 g/d in women and 10-39 g/d in men), and high alcohol intake. Cox proportional hazards models were used to describe the association between alcohol consumption and cardiovascular disease-free survival (combined endpoint), cardiovascular disease events (CADE) and overall survival. Baseline and time-updated risk factors for CADE were included in the models.

Results: Among 9741 individuals included, there were 788 events of major CADE or death during 46,719 patient-years of follow-up, corresponding to an incidence of 1.69 events/100 person-years. Follow-up according to alcohol consumption level was 51% no or very low, 20% low, 23% moderate, and 6% high intake. As compared with no or very low alcohol intake, low (hazard ratio 0.79, 95% confidence interval 0.63 to 0.98) and moderate alcohol intakes (0.78, 0.64 to 0.95) were associated with a lower incidence of the combined endpoint. There was no significant association between alcohol consumption and CADE.

Conclusions: Compared with no or very low alcohol consumption, low and moderate intake associated with a better CADE-free survival. However, this result was mainly driven by mortality and the specific impact of drinking patterns and type of alcoholic beverage on this outcome remains to be determined.

Keywords
  • Adult
  • Alcohol Drinking
  • Alcoholic Beverages
  • Cardiovascular Diseases / epidemiology
  • Cohort Studies
  • Dose-Response Relationship, Drug
  • Female
  • HIV Infections / complications
  • HIV Infections / epidemiology
  • HIV Infections / mortality
  • Humans
  • Male
  • Middle Aged
  • Switzerland / epidemiology
Research groups
Citation (ISO format)
WANDELER, Gilles et al. The J-Curve in HIV: Low and Moderate Alcohol Intake Predicts Mortality but Not the Occurrence of Major Cardiovascular Events. In: Journal of acquired immune deficiency syndromes, 2016, vol. 71, n° 3, p. 302–309. doi: 10.1097/QAI.0000000000000864
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1525-4135
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