Scientific article
Open access

Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults

Published inNature aging, vol. 3, no. 1, p. 105-120
Publication date2023-01-12
First online date2023-01-12

Basic emotional functions seem well preserved in older adults. However, their reactivity to and recovery from socially negative events remain poorly characterized. To address this, we designed a 'task-rest' paradigm in which 182 participants from two independent experiments underwent functional magnetic resonance imaging while exposed to socio-emotional videos. Experiment 1 (N = 55) validated the task in young and older participants and unveiled age-dependent effects on brain activity and connectivity that predominated in resting periods after (rather than during) negative social scenes. Crucially, emotional elicitation potentiated subsequent resting-state connectivity between default mode network and amygdala exclusively in older adults. Experiment 2 replicated these results in a large older adult cohort (N = 127) and additionally showed that emotion-driven changes in posterior default mode network-amygdala connectivity were associated with anxiety, rumination and negative thoughts. These findings uncover the neural dynamics of empathy-related functions in older adults and help understand its relationship to poor social stress recovery.

  • Aged
  • Amygdala / diagnostic imaging
  • Brain Mapping
  • Brain / diagnostic imaging
  • Emotions
  • Humans
  • Magnetic Resonance Imaging
  • European Commission - Investigating the impact of meditation training on mental health and wellbeing in the ageing population [667696]
Citation (ISO format)
BAEZ LUGO, Sebastian et al. Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults. In: Nature aging, 2023, vol. 3, n° 1, p. 105–120. doi: 10.1038/s43587-022-00341-6
Main files (2)
Article (Published version)
Article (Accepted version)
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ISSN of the journal2662-8465

Technical informations

Creation07/12/2023 4:53:45 PM
First validation07/17/2023 9:38:23 AM
Update time07/17/2023 9:38:23 AM
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